Results 81 to 90 of about 133,869 (230)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Self-Sampled Gargle Water Direct RT-LAMP as a Screening Method for the Detection of SARS-CoV-2 Infections

Diagnostics, 2022
We assessed the viability of self-sampled gargle water direct RT-LAMP (LAMP) for detecting SARS-CoV-2 infections by estimating its sensitivity with respect to the gold standard indirect RT-PCR of paired oro-nasopharyngeal swab samples.
Skaiste Arbaciauskaite, Pouya Babakhani, Natalia Sandetskaya, Dalius Vitkus, Ligita Jancoriene, Dovile Karosiene, Dovile Karciauskaite, Birute Zablockiene, Dirk Kuhlmeier   +8 more
doaj   +1 more source

Effectiveness of a Modified Skull Model for Nasopharyngeal Swab Training among Undergraduate Medical Students: A Prospective Interventional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Nasopharyngeal swab collection is considered one of the most sensitive methods for obtaining upper respiratory tract specimens; however, it requires adequate anatomical understanding and proper technique.
Poornima S Bhat, K Santhana Krishnan, M Nisha, Vanshika Singhal   +3 more
doaj   +1 more source

Diagnostic performance of patient self-collected oral swab (tongue and cheek) in comparison with healthcare worker-collected nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 detection

, 2022
Diagnostic performance of patient self-collected oral swab (tongue and cheek) in comparison with healthcare worker-collected nasopharyngeal swab for severe acute respiratory syndrome coronavirus-2 ...
Vikalp Bhoi (16700187), Samiran Panda (3595097), Arati Mane (157594), Swarali Kurle (281617), Vijay Nema (9520871), Michael Pereira (13089027), Atul Sirsat (16700181), Gaurav Pathak (16700184), Shailaja Bhavsar (16700190), Shilpa Jain (402115), Ankita Jain (5116730), Vandana Saxena (421619)   +11 more
core  

The VCPIP1‐UBE3A Deubiquitination‐Ubiquitination Cascade Contributes to Castration‐Resistant Prostate Cancer Progression

Advanced Science, EarlyView.
VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin, Wen‐Cai Zheng, Yi‐Qiu Wang, Bin Lin, Yun‐Zhi Lin, Dong‐Ning Chen, Xiao‐Dong Li, Xue‐Yi Xue, Yong Wei, Ning Xu   +9 more
wiley   +1 more source

3D-printed simulator for nasopharyngeal swab collection for COVID-19

, 2020
Introduction: Testing for COVID-19 is a cornerstone of pandemic control. If conducted inappropriately, nasopharyngeal swab collection can be painful and preanalytical sample collection errors may lead to false negative results.
Lodi, Massimo, Koch, Antoine, Lefebvre, Nicolas, Sananès, Axel, Debry, Christian, Sananès, Nicolas, Lecointre, Lise, Axel Sananès, Sananès, N. (Nicolas), Lefebvre, N. (Nicolas), Nicolas Lefebvre, Antoine Koch, Lise Lecointre, Sananès, A. (Axel), Nicolas Sananès, Lecointre, L. (Lise), Massimo Lodi, Lodi, M. (Massimo), Christian Debry, Debry, C. (Christian), Koch, A. (Antoine)   +20 more
core   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

A flowsheet of full-time and contracted who were tested for SARS-CoV-2 infection by PCR on a nasopharyngeal swab and for SARS-CoV-2 antibody.

, 2021
A flowsheet of full-time and contracted who were tested for SARS-CoV-2 infection by PCR on a nasopharyngeal swab and for SARS-CoV-2 antibody.
Abdul-Badi Abou-Samra (3411167), Jameela Al-Ajmi (11506580), Moza Alishaq (11506562), Adeel Ajwad Butt (11506601), Diana H. Jboor (11506574), Rosaline Saba (11506577), Sameera Bihi Fareh (11506589), Zeina Al-Kanaani (11506568), Hanaa Nafady-Hego (11506571), Nasser Asad Alansari (11506583), Nadya Alanzi (11506598), Suni Vinoy (11506592), Anil George Thomas (11506586), Maryam Nooh (11506595), Andrew Jeremijenko (11506565)   +14 more
core   +1 more source

Simple concentration method enables the use of gargle and mouthwash instead of nasopharyngeal swab sampling for the diagnosis of COVID-19 by PCR [PDF]

, 2021
Since its emergence in December 2019, SARS-CoV-2 is causing one of the most devastating pandemics in human history. Currently, the most important method for definitive diagnosis of COVID-19 is identification of SARS-CoV-2 RNA in nasopharyngeal ...
Aksoy, Ece, Mozioglu, Erkan, Karakus, Betul, Cankaya, Dilara, Kocagoz, Tanil, Polat, Tuba, Yurttutan Uyar, Neval, Kocagoz, Sesin, Can, Ozge   +8 more
core   +1 more source