Results 131 to 140 of about 23,350,035 (239)

Breaking down barriers in building teacher competence [PDF]

, 2012
Teachers may well be made, not born, and appointments to academic positions are often made without regard to the appointee’s prior experience or competence in teaching.
Bruce Ferguson, Pip, Bruce Fergusson, Pip   +1 more
core  

Process, Rationale, and Interventions of Pakistan’s National Action Plan on Chronic Diseases

Preventing Chronic Disease, 2005
Most developing countries do not comprehensively address chronic diseases as part of their health agendas because of lack of resources, limited capacity within the health system, and the threat that the institution of national-level programs will weaken ...
Sania Nishtar, PhD, FRCP, Khalif Mohamud Bile, PhD, Ashfaq Ahmed, MBBS, Azhar M.A. Faruqui, FRCP, Zafar Mirza, MPH, Samad Shera, FRCP, Abdul Ghaffar, PhD, Fareed A. Minhas, FRCP, Aslam Khan, FRCP, MRCP, Naeem A. Jaffery, FRCP, Majid Rajput, MPH, FCPS, Yasir A. Mirza, MSc, Mohammad Aslam, MSc, FCPS,, Ejaz Rahim, MA   +13 more
doaj  

National Action Plan in Antimicrobial Resistance Using Framework Analysis for China. [PDF]

China CDC Wkly, 2023
Chen S, Zhang J, Wu Y.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Qualitative Study on the Policy Process and Development of the National Action Plan on Antimicrobial Resistance in Singapore. [PDF]

Antibiotics (Basel), 2023
Chua AQ, Verma M, Azupardo K, Lota MM, Hsu LY, Legido-Quigley H.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

European Union's Action Plan on Antimicrobial Resistance and Implications for Trading Partners with Example of National Action Plan for Croatia

Asian Fisheries Science, 2020
Snježana Zrnčić
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source