Results 171 to 180 of about 219,094 (263)

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Global research status in the treatment of glaucoma: a systematic bibliometric analysis. [PDF]

Int J Ophthalmol
Liu WH, Shu C, Jia BD, Li XR.
europepmc   +1 more source

Geopolitical Risk and Domestic Bank Deposits

Financial Management, EarlyView.
ABSTRACT We investigate the relationship between global geopolitical risk and bank deposit flows across a wide panel of European countries. Motivated by the pivotal role of deposit stability for financial intermediation and systemic resilience, we explore whether geopolitical shocks alter depositors’ portfolio choices.
Dimitris Anastasiou, Theodore Kapopoulos, Steven Ongena, Athanasios Sakkas   +3 more
wiley   +1 more source

Host-Associated Bacterial Community Changes After Laboratory Introduction Vary With Wolbachia Presence. [PDF]

Environ Microbiol
Brinker P, Salles JF, Beukeboom LW, Fontaine MC.   +3 more
europepmc   +1 more source

Reputation and Asset Prices: Evidence From Trump Real Estate

Financial Management, EarlyView.
ABSTRACT We analyze the impact of brand reputation on asset prices by exploiting the prominence of Donald Trump in Manhattan real estate. Our quasi‐experiment identifies a 14.5% discount to condominiums in Trump‐branded buildings after controversies surrounding Trump's presidential candidacy began in June 2015 up to 2022.
Marlene Koch, Simon Stehle, Rémi Vivès
wiley   +1 more source

Macronutrient concentrations in human milk beyond the first half year of lactation: a cohort study. [PDF]

Arch Dis Child Fetal Neonatal Ed
Muts J, Lukowski JIA, Twisk JWR, Schoonderwoerd A, van Goudoever JB, van Keulen BJ, Van Den Akker CHP.   +6 more
europepmc   +1 more source

The Impact of Periodontitis on Oral Health Outcomes in Older Adults: A Systematic Review

Gerodontology, EarlyView.
ABSTRACT Objective To systematically review the impact of periodontitis on clinical oral health outcomes and oral health‐related quality of life (OHRQoL) in older adults (≥ 60 years). Background Global evidence shows that severe periodontitis prevalence peaks in the 60s, yet how periodontitis relates specifically to oral health outcomes in older adults
Lewis Winning, Kristina Bertl, Ioannis Polyzois, Yvonne Van der Waal, Rawan Kahatab, Peter Harrison, Gerry McKenna   +6 more
wiley   +1 more source

Increased incidence, survival, and registration quality of primary hepato-pancreato-biliary cancers in the Netherlands Cancer Registry. [PDF]

Int J Cancer
van der Geest LG, van der Mark M, Verheij J, Farina Sarasqueta A, de Vos-Geelen J, Besselink MG, de Meijer VE, de Hingh IHJT, Bonsing BA, de Reuver PR, Willemssen FEJA, Vissers PAJ, Visser O, Dutch Pancreatic Cancer Group and the Dutch Hepatocellular & Cholangiocarcinoma Group.   +13 more
europepmc   +1 more source

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

Hepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami, Soranobu Ninomiya, Takayasu Ideta, Ayumu Kanbe, Toshihide Maeda, Daisuke Minowa, Daisuke Taguchi, Masaya Kubota, Hiroyasu Sakai, Kenji Imai, Yasuko Yamamoto, Hiroyasu Ito, Kuniaki Saito, Osamu Yoshida, Yoichi Hiasa, Masahito Shimizu   +15 more
wiley   +1 more source

Best clinical practise guidance for the use of antibiotics in children: an EAPD policy document. [PDF]

Eur Arch Paediatr Dent
Rajasekharan S, Lygidakis N, Cauwels R, Declerck D, Monteiro J, Parekh S.   +5 more
europepmc   +1 more source