Results 101 to 110 of about 995,138 (341)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The impact of the reference price system on the pharmaceutical market: A theoretical approach [PDF]

This article analyses the impact of the reference price system on the price-setting strategies of the pharmaceutical firms and on the level of generic usage.
Anna Merino
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

STORE VS. NATIONAL BRANDS: A PRODUCT LINE MIX PUZZLE [PDF]

This paper examines retailers' strategic decisions about store brand introduction when each retailer can stock a limited number of brands. The different product line mix equilibria depend on demand parameters that measure the cross-effect across national
Amparo Urbano, José J. Sempere Monerris, Rafael Moner Colonques   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Geographic origin discrimination and quantification of phenolic compounds and moisture in Artemisia argyi folium using NIRS and chemometrics

Journal of Agriculture and Food Research
Artemisia argyi Folium (AAF), the leaf of the perennial plant Artemisia argyi H. Léveillé & Vaniot, has a long history of medicinal and edible use in East Asia.
Lifei Hu, Yifan Wang, Xin Wu, Yuanyuan Shan, Fengxiao Zhu, Fan Zhang, Qiang Yang, Mingxing Liu   +7 more
doaj   +1 more source

Structural Model of Retail Market Power: The U.S. Milk Industry [PDF]

The objective of our research is to investigate retailer market conduct in the sale of beverage milk using a structural model of consumer behavior and retailer optimality conditions that embrace a range of competitive scenarios.
Gould, Brian W., Hovhannisyan, Vardges
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Stimulus-Organism-Response (SOR) Paradigm in Country of Origin, Brand Experience, Customer Satisfaction, Brand Loyalty: The National Cultural Inheritance Matters

Southeast Asian Business Review
Indonesia, with its rich cultural heritage and philosophy, has many traditional art patterns and techniques on fashion, especially Batik, which UNESCO declared a Masterpiece of the Oral and Intangible Heritage of Humanity in 2008.
Maria Mia Kristanti
doaj   +1 more source

Consumer Response to Brand Placement in Movies: Investigating the Brand-Event Fit

Vikalpa, 2016
Executive Summary Movies offer the perfect media site for placement of brands as part of the emerging marketing strategy. Although attempts to analyse brand placements have been made in the past, the same needs more attention in the Indian context. Given
Komal Nagar
doaj   +1 more source