Results 31 to 40 of about 57,159 (140)

Impact of COVID-19 Pandemic on Medical Practices

Asian Pacific Journal of Cancer Care, 2022
The COVID-19 pandemic has affected human life in all spheres. However, the medical and health practices seen changed a lot since the arrival of this pandemic. This article describes the positive and negative impact of covid in the medical field.
Balbir Kumar, Rakesh Garg, Prashant Sirohyia, Brajesh Kumar Ratre, Ram Singh   +4 more
doaj   +1 more source

In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression

Molecular Systems Biology, 2020
The COVID‐19 pandemic caused by SARS‐CoV‐2 has been a global health challenge. Angiotensin‐converting enzyme 2 (ACE2) is the host receptor for SARS‐CoV‐2 entry.
Sanju Sinha, Kuoyuan Cheng, Alejandro A Schäffer, Kenneth Aldape, Eyal Schiff, Eytan Ruppin   +5 more
doaj   +1 more source

National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library [PDF]

ACS Chemical Biology, 2020
An automated, high-capacity, and high-throughput procedure for the rapid isolation and identification of biologically active natural products from a prefractionated library is presented. The semipreparative HPLC method uses 1 mg of the primary hit fraction and produces 22 subfractions in an assay-ready format.
Tanja Grkovic, Rhone K. Akee, Christopher C. Thornburg, Spencer K. Trinh, John R. Britt, Matthew J. Harris, Jason R. Evans, Unwoo Kang, Susan Ensel, Curtis J. Henrich, Kirk R. Gustafson, Joel P. Schneider, Barry R. O’Keefe   +12 more
openaire   +2 more sources

Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination Therapy [PDF]

, 2013
Recent tumor sequencing data suggest an urgent need to develop a methodology to directly address intratumoral heterogeneity in the design of anticancer treatment regimens.
Hemann, Michael, Lauffenburger, Douglas A, Pritchard, Justin R., Zhao, Boyang   +3 more
core   +2 more sources

Lessons learned from different prognostic factors analysis in intermediate-risk neuroblastoma: ten years’ experience at a tertiary center

Journal of the Egyptian National Cancer Institute
Background Intermediate-risk (IR) neuroblastoma represents a biologically and clinically diverse group of tumors. This study evaluates the feasibility of surgical excision and identifies prognostic factors that influence survival in IR-neuroblastoma ...
Mustafa Selim, Hanafy Hafez, Abeer M. Elsayed, Mohamed Shalaby, Abdalwahab R. Abdalwahab, Soad A. Eltokhy, Mohamed Fawzy   +6 more
doaj   +1 more source

Growth in eligibility criteria content and failure to accrue among National Cancer Institute (NCI)‐affiliated clinical trials

Cancer Medicine, 2022
AbstractBackgroundCancer trial accrual is a national priority, yet up to 20% of trials fail to accrue. Trial eligibility criteria growth may be associated with accrual failure. We sought to quantify eligibility criteria growth within National Cancer Institute (NCI)‐affiliated trials and determine impact on accrual.MethodsUtilizing the Aggregated ...
John S. Peterson, Deborah Plana, Danielle S. Bitterman, Skyler Bryce Johnson, Hugo J. W. L. Aerts, Benjamin Harris Kann   +5 more
openaire   +4 more sources

The Big Squeeze: A Social and Political History of the Controversial Mammogram [PDF]

, 2012
[Excerpt] The Big Squeeze: A Social and Political History of the Controversial Mammogram chronicles the often turbulent history of screening mammography since its introduction in the early 1970s. This book makes five key points.
Reynolds, Handel, MD
core   +2 more sources

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition [PDF]

, 2018
Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor ...
Alan H. Shih, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Andrew M. Intlekofer, Anna Sophia McKenney, April Chiu, Barbara Spitzer, Craig B. Thompson, Efthymia Papalexi, Elizaveta Freinkman, Esra A. Akbay, Franck T. Rapaport, Gaujoux, Jihae Ahn, Julie Teruya-Feldstein, Kaitlyn Shank, Katharine Yen, Kwok-Kin Wong, Matthew G. Vander Heiden, Mesa, Minal A. Patel, Mya Steadman, Raajit Rampal, Raj Nagaraja, Ross L. Levine, Stein, Tefferi   +26 more
core   +1 more source

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

ACS Omega, 2023
National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI's 60 ...
Jason R. Evans, Rhone K. Akee, Shaurya Chanana, Grant D. McConachie, Christopher C. Thornburg, Tanja Grkovic, Barry R. O’Keefe   +6 more
openaire   +2 more sources

Clinicopathological and prognostic insights into Embryonal Tumors with Multilayered Rosettes (ETMRs)

Diagnostic Pathology
Background Embryonal tumors with multilayered rosettes (ETMRs) are rare, highly aggressive pediatric brain neoplasms characterized by early onset and dismal prognosis. This study presents a comprehensive clinicopathological and molecular analysis of ETMR
Noura A. A. Ebrahim, Heba A. Abdelbaky, Ahmed Mustafa Abd Elsalam, Mustafa A Hussein, Nancy H Amin   +4 more
doaj   +1 more source