Results 41 to 50 of about 56,784 (131)

National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

ACS Omega, 2023
National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI's 60 ...
Jason R. Evans, Rhone K. Akee, Shaurya Chanana, Grant D. McConachie, Christopher C. Thornburg, Tanja Grkovic, Barry R. O’Keefe   +6 more
openaire   +2 more sources

Clinicopathological and prognostic insights into Embryonal Tumors with Multilayered Rosettes (ETMRs)

Diagnostic Pathology
Background Embryonal tumors with multilayered rosettes (ETMRs) are rare, highly aggressive pediatric brain neoplasms characterized by early onset and dismal prognosis. This study presents a comprehensive clinicopathological and molecular analysis of ETMR
Noura A. A. Ebrahim, Heba A. Abdelbaky, Ahmed Mustafa Abd Elsalam, Mustafa A Hussein, Nancy H Amin   +4 more
doaj   +1 more source

Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model

BMC Chemistry, 2022
Background The difficulty of achieving targeted drug delivery following administration of presently marketed anticancer therapeutics is still a concern. Metallic nanoparticles (NPs) appear to be promising in this regard.
Amna H. Faid, Samia A. Shouman, Yehia A. Badr, Marwa Sharaky   +3 more
doaj   +1 more source

Source, pattern and antibiotic resistance of blood stream infections in hematopoietic stem cell transplant recipients

Journal of the Egyptian National Cancer Institute, 2014
Mucositis developing as a result of myelo-ablative high dose therapy administered prior to hematopoietic stem cell transplantation (HSCT) is associated with the risk of bacteremia.
Hadir El-Mahallawy, Iman Samir, Raafat Abdel Fattah, Dalia Kadry, Amany El-Kholy   +4 more
doaj   +1 more source

Current Status of Biparametric MRI in Prostate Cancer Diagnosis: Literature Analysis

Life, 2022
The role of multiparametric MRI (mpMRI) in the detection of prostate cancer is well-established. Based on the limited role of dynamic contrast enhancement (DCE) in PI-RADS v2.1, the risk of potential side effects, and the increased cost and time, there ...
Mason James Belue, Enis Cagatay Yilmaz, Asha Daryanani, Baris Turkbey   +3 more
doaj   +1 more source

From biomarker to targeted therapy: investigating trophoblast cell-surface antigen 2 expression in triple-negative breast cancer– insights from the national cancer institute

BMC Cancer
Background Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior and limited treatment options, primarily due to the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor ...
Noura A. A. Ebrahim, Mustafa A. Hussein, Mohamed Emam Sobeih, Nancy H. Amin   +3 more
doaj   +1 more source

Sphincter saving and abdomino-perineal resections following neoadjuvant chemoradiation in locally advanced low rectal cancer

Journal of the Egyptian National Cancer Institute, 2015
Background: The improvement in surgical techniques alongside neoadjuvant chemoradiation enabled more patients with low rectal cancer to have sphincter preservation.
W. Gawad, I. Fakhr, M. Lotayef, O. Mansour, N. Mokhtar   +4 more
doaj   +1 more source

Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

EJNMMI Research, 2021
Background PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides.
Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke, Frank I. Lin   +14 more
doaj   +1 more source

Adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations and risk of lifestyle-related cancers in the prostate, lung, colorectal, and ovarian cancer screening trial

BJC Reports
Background The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) Cancer Prevention Recommendations aim to lower cancer incidence.
Fiona C. Malcomson, Marissa M. Shams-White, Jill Reedy, Wen-Yi Huang, Steven C. Moore, Erikka Loftfield   +5 more
doaj   +1 more source

Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics

Nature Communications
Alternative splicing is a pervasive gene regulatory mechanism critical for diversifying the human proteome. To systematically investigate its role in cell fate determination, we develop scCHyMErA-Seq, a scalable CRISPR-based exon deletion screening ...
Bandana Kumari, Arun Prasath Damodaran, Wilfried M. Guiblet, Mei-Sheng Xiao, Amit K. Behera, Tyler A. On, Carl E. McIntosh, Maxwell Teszler, Chelsee Holloway, Sandra Le, Nikhil Parab, Yongmei Zhao, Michael Aregger, Thomas Gonatopoulos-Pournatzis   +13 more
doaj   +1 more source