Results 71 to 80 of about 2,388,117 (306)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Quantitative Methodology for Measuring Natural Character in New Zealand's Coastal Environments [PDF]

, 2011
Anecdotal evidence points to an overall loss of coastal natural character in New Zealand since preserving the natural character of the coastal environment first became a statutory policy-goal in 1973.
Froude, Victoria Ann
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

VALUES IN THE QUOTES OF ARCHIPELAGO AND THEIR RELEVANCE WITH CHARACTER BUILDING EDUCATION [PDF]

, 2011
One of the hottest issues in Indonesia is national character building. National character building was the theme of the National Education Day May 2, 2011. The aim of this paper is to present local wisdoms in the Archipelago, i.e.
Firmawan, Hendro, Purwaningsih, Endang, Said, Mashadi, Sujana, Sujana   +3 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Adaptive recommendation of student-created micro-lessons based on learning style and knowledge-level modeling

Discover Education
Intelligent tutoring system (ITS) are increasing in both intelligence and precision over time, as the demand for personalization grows and procedures become more standardized.
Doniyorbek Ahmadaliev, Chen Xiaohui, Zhe Zhang, Anvarjon Makhmudov, Mukharramoy Akhmadalieva, Amirov Islombek   +5 more
doaj   +1 more source

“The world is in Amsterdam”: Amsterdam, the Netherlands, and the Dutch in Guinevere Glasfurd’s The Words in My Hand

American and British Studies Annual, 2021
The article presents an imagological study of the recent historical novel The Words in My Hand (2016) by British author Guinevere Glasfurd with the focus on how the Dutch and the 17th century Netherlands are portrayed in the novel, especially regarding ...
Lenka Žárská
doaj  

Developing Cultural And Character Nations Values Through Mathematics Learning [PDF]

, 2011
Education is an attempt to improve the quality of youth in various aspects for the sustainability of society and the nation’s live better in the future.
Bambang , Priyo Darminto
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source