Results 71 to 80 of about 1,641,247 (266)

The impact of national culture in the development of complexity reasoning skills: An international comparison. [PDF]

open access: yesHeliyon, 2023
Rodríguez-Abitia G   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The Cross-Cultural Communications in Business Trips: Statistical Measures in Coordinates of Ukraine

open access: yesCommunications, 2019
The purpose of this study is to find ways to increase the effectiveness of cross-cultural communications from the standpoint of Ukrainian business. The methodology of the research is based on statistical measures; there is quantitative identification of ...
Yaroslav Martynyshyn   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Socio-Cultural Contradictions in the Development of the Regional Restaurant Services Consumer Market in Ukraine

open access: yesSocio-Cultural Management Journal
Introduction. The article explores the sociocultural contradictions accompanying the development of the consumer market of regional restaurant services in Ukraine.
Olha Danylenko   +2 more
doaj   +1 more source

Analysis of the physical development and somatotype of girls and females involved into dancing and gymnastic sports

open access: yesPhysical Education of Students, 2019
Purpose: the comparative analysis of the physical development and somatotype of girls and females involved in dancing and gymnastic sports (acrobatic rock and roll, sports aerobics) Material: The study involved 45 girls and females.
L.V. Podrigalo   +7 more
doaj   +1 more source

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