Results 31 to 40 of about 138,913 (312)
Journal of Obstetrics and GynaecologyBackground Menopause is linked to declining ovarian function and adverse health outcomes such as cardiovascular disease and osteoporosis. Early menopause exacerbates these risks, underscoring the need to identify modifiable risk factors.
Liping Wang +4 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Prevalence and comorbidity burden of clinical obesity in US adults
BMC Public HealthBackground This study aimed to estimate the prevalence and comorbidity burden of clinical obesity among US adults. Methods Analyzing data from 53,333 US adults (NHANES, 1999–2018), we stratified participants into no obesity, preclinical obesity, and ...
Tuo Xiao +4 more
doaj +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
BMC Public HealthObjective This study aims to investigate the relationship between obesity and constipation among American adults. Methods Our study leveraged data from the National Health and Nutrition Examination Survey (NHANES).
Nengjun Xiang +3 more
doaj +1 more source
Caffeine Consumption and Mortality in Diabetes: An Analysis of NHANES 1999–2010
Frontiers in Endocrinology, 2018 Aim: An inverse relationship between coffee consumption and mortality has been reported in the general population. However, the effect of coffee consumption in diabetes remains unclear.
João Sérgio Neves +9 more
doaj +1 more source
Shiftwork and Prostate-Specific Antigen in the National Health and Nutrition Examination Survey [PDF]
JNCI Journal of the National Cancer Institute, 2013 Shiftwork has been implicated as a risk factor for prostate cancer. Results from prior studies have been mixed but generally support an association between circadian disruption and prostate cancer. Our aim was to investigate the relationship between shiftwork and prostate-specific antigen (PSA) test obtained as part of the National Health and Nutrition
Flynn-Evans, E.E. +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
American Journal of Preventive CardiologyBackground: The American Heart Association has recently updated its definition of what constitutes cardiovascular health (CVH), known as Life’s Essential 8 (LE8).
Jiangtao Li, Xiang Wei
doaj +1 more source