Results 141 to 150 of about 2,764,193 (353)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Impact of age, HIV1, sickle-cell genotypes, and interferon-gamma gene upstream variants on malaria disease outcomes in a longitudinal pediatric cohort

Scientific Reports
This prospective cohort study explored the association between two upstream IFN-γ variants (rs2069709: G > T and rs2069705: A > G) and hazard factors for malaria outcomes in a longitudinal cohort of children (n = 941, 3–36 mos.), followed for three years.
Evans Raballah, Samuel B. Anyona, Shamim W. Osata, Sharley A. Wasena, Clinton Onyango, Ivy Hurwitz, Qiuying Cheng, Philip D. Seidenberg, Benjamin H. McMahon, Collins Ouma, John M. Ong’echa, Kristan A. Schneider, Douglas J. Perkins   +12 more
doaj   +1 more source

Community health volunteers’ contribution to Tuberculosis patients notified to National Tuberculosis program through contact investigation in Kenya [PDF]

, 2020
Tabitha Abongo, Benson Ulo, Sarah Karanja   +2 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Health-Care Access For The Elderly Of Industrialized Nations: Fallen And Can\u27t Get Up? [PDF]

, 1997
Canada, and England have developed and funded national health programs in keeping with this entitlement philosophy. The United States government, though stopping short of providing every citizen health-care access as a right,\u27 has entitled various ...
Babiak, Joann
core   +1 more source

Satisfaction of the primary care, mental health, and dental health clinicians of the national health service corps loan repayment program

, 2021
T. Rauner, D.E. Pathman, J. Fannell, R.G. Sewell, T.R. Konrad   +4 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

EFFECTIVE IMPLEMENTATION OF NATIONAL HEALTH PROGRAMS: ISSUES AND CHALLENGES

National Journal of Medical Research, 2012
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Satya Ranjan Lenka, Sitanshu Sekhar Kar   +1 more
doaj  

Management Capacity Assessment for National Health Programs: A study of RCH Program in Gujarat State [PDF]

The Ministry of Health and Family Welfare, Government of India administers a large number of national health programs such as Malaria control program, Blindness control program, National AIDS control program, Reproductive and Child Health (RCH) Program ...
Mavalankar, Dileep, Ramani, K. V.
core