Results 51 to 60 of about 1,618,479 (311)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Ballot initiatives and the national debate on immigration
Transatlantica, 2012 Proposition 187 voted by Californians in 1994 was the first in a long series of ballot initiatives proposed by other states limiting access to welfare programs and education to illegal immigrants.
Mario Menéndez
doaj +1 more source
Intitatives for a Smart Economy 2.0 [PDF]
, 2017 Just like its predecessor, I4SE 2.0 is organized in a manner that focuses on those sectors of the local economy identified by WNYREDC as growth sectors.
Poloncarz, Mark
core +1 more source
Sport and exercise medicine and the Olympic health legacy [PDF]
, 2012 London 2012 is the first Olympic and Paralympic Games to explicitly try and develop socioeconomic legacies for which success indicators are specified - the highest profile of which was to deliver a health legacy by getting two million more people more ...
Copeland, Robert +2 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Liver Research, 2019 Estrogen-related receptor gamma (ERRγ) is one of three members of the ERR family and remains an orphan, as there are no known natural ligands. ERRγ is an inducible transcription factor, and its ligand-independent transcriptional activity is regulated by ...
Don-Kyu Kim, Hueng-Sik Choi
doaj +1 more source
School to where? A literature review on economic outcomes of youth with Disabilities [PDF]
, 2002 This paper summarizes the recent empirical literature on post-secondary school outcomes of youth with disabilities. Our summary illustrates the variation in characteristics and outcomes that exist in several subpopulations generally defined as youth with
Maag, Elaine, Wittenburg , David C.
core +1 more source