Results 41 to 50 of about 606,689 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

RETRACTED: INNOVATION ACTIVITIES: INDICATORS AND IMPLEMENTATION METHODS

Модернизация, инновация, развитие, 2016
Retracted articleInnovation is a new development in the field of technology, work organization or management that provides for increased efficiency. Today, the innovation process has become nonlinear.
A. L. Gaponenko, S. V. Pirogov, I. F. Chernyavski   +2 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

MACEDONIAN NATIONAL INNOVATION SYSTEM – MAIN CHALLENGES

Economic Review, 2014
It is generally accepted that the National Innovation Systems (NIS) are one of the most comprehensive systemic approaches that give insight into innovative and economic performance of a country.
Radmil Polenakovik, Ivana Stankovska, Bojan R. Jovanovski   +2 more
doaj   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

State of the arts and innovation : before and after the review of the national innovation system

, 2009
This article examines the relationship between the arts and national innovation policy in\ud Australia, pivoting around the Venturous Australia report released in September 2008 as part\ud of the Review of the National Innovation System (RNIS). This came
Jaaniste, Luke O.
core   +1 more source

Broadening the national focus in technological innovation system analysis: The case of offshore wind [PDF]

, 2015
This paper empirically explores if and how the spatial dimensions of Technological Innovation System matter using the case of offshore wind in North-Western Europe.
Coenen, Lars, Wieczorek, Anna J., Energy, Resources & Technological Change, Energy and Resources, Wieczorek, AJ Anna, Hekkert, M.P., Coenen, L., Harmsen, R., Harmsen, Robert, Hekkert, Marko P., Wieczorek, A.J., Innovation Studies, Dynamics of Innovation Systems, Hekkert, Marko P   +13 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Learning towards system innovation: Evaluating a systemic instrument

, 2010
In this paper we develop an analytical framework for studying learning processes in the context of efforts to bring about system innovation by building new networks of actors who are willing to work on a change towards sustainable development.
Klein Woolthuis, R., Smits, R.E.H.M., Klein Woolthuis, Rosalinde, van Mierlo, B.C., Mierlo, Barbara van, Mierlo, B. van, Leeuwis, C., van Mierlo, B., Smits, R., Mierlo, B.C., van, Leeuwis, Cees, Klein Woolthuis, R.J.A.   +11 more
core   +1 more source