Results 51 to 60 of about 35,883,944 (304)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Cocoa farmers' characteristics on climate variability and its effects on climate change adaptation strategy [PDF]

Global Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Climate change has a greater influence on agriculture through local climate variability than global climate patterns. The impact of climate change on agricultural productivity and shifts in crop patterns varies significantly ...
I. Idawati, N.A. Sasongko, A.D. Santoso, M. Septiani, T. Handayani, A.Y.N. Sakti, B.D. Purnamasari   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

РАЗВИТИЕ ВЫСШЕГО ОБРАЗОВАНИЯ В ФОРМИРОВАНИИ НАЦИОНАЛЬНОЙ ИННОВАЦИОННОЙ СИСТЕМЫ ЭКВАДОРА

Вестник Северо-Кавказского федерального университета, 2022
The Republic of Ecuador has shown significant successes in socio-economic development against the backdrop of several Latin American countries. So, Ecuador is in 123rd place out of 190, which make up the Doing Business rating. In terms of GDP, Ecuador is
T. Kolmykova, V. R. Calderon
doaj  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

APPROACHES TO EVALUATING INNOVATIVE POTENTIAL OF THE COUNTRY'S ECONOMY

Вестник Северо-Кавказского федерального университета, 2022
Challenges to the sustainable development of countries are intensifying due to globalization processes and constantly growing international competition.
O. Lashkareva, G. Kozhakmetova
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

State of the arts and innovation : before and after the review of the national innovation system

, 2009
This article examines the relationship between the arts and national innovation policy in\ud Australia, pivoting around the Venturous Australia report released in September 2008 as part\ud of the Review of the National Innovation System (RNIS). This came
Jaaniste, Luke O.
core   +1 more source

THE ROLE OF INNOVATION POLICY IN THE NATIONAL INNOVATION SYSTEM: THE CASE OF ESTONIA; pp. 249–272 [PDF]

Trames, 2015
The article highlights the unifying role of innovation policy in shaping and ensuring the functioning of a national innovation system. The first part of the article deals with the need for public sector intervention in innovation processes.
Janno Reiljan, Ingra Paltser
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source