Results 61 to 70 of about 35,883,944 (304)

Directions of Development of National Innovation System

Модернизация, инновация, развитие, 2017
Purpose: to study the feasibility of building a national innovation system on the principles of rational self-sufficiency of the domestic economy. Methods: during research following methods were applied: comparative and correlative analysis, correlations,
Artur D. Bobryshev, Maria V. Chekadanova
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Aspects of Properly-Functioning National Innovation System: The Case of Latvia [PDF]

Societas et Iurisprudentia, 2013
Innovation support policies should take into consideration all particular qualities of national innovation system in the country, not being one-size-fits-all, in this case, the analysis of strengths and weaknesses of national innovation system is ...
Daina Šķiltere, Svetlana Jesiļevska
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Experiences and user perceptions of virtual-reality-based mindfulness interventions: protocol for a systematic review and thematic synthesis

BMJ Open
Introduction Virtual reality (VR) technology is increasingly being explored as a medium for delivering mindfulness-based interventions. While studies have investigated the feasibility and efficacy of VR-based mindfulness interventions, there has been ...
Amartya Mukhopadhyay, Amanda Yap, Ravi Shankar, Anjali Bundele   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Current scenario and potential of waste cooking oil as a feedstock for biodiesel production in Indonesia: Life cycle sustainability assessment (LCSA) review

Case Studies in Chemical and Environmental Engineering
WCO is a second-generation biofuel made up of accumulated free fatty acids, which can be used as feedstock for biodiesel production. The review aims to: (a) evaluate the sustainability of waste cooking oil (WCO) for biodiesel production in Indonesia ...
Arif Rahman, M.A.M. Oktaufik, Triyono Widi Sasongko, Iwan Guntoro, Dadi Soedjati, Najmi Abbas, Abdul Rahman, Fathiah Ulfah, Ari Widiarto, Siswanto, Dharmawan, Sudarwaji Edi Yuwono Trihadi, Kusrestuwardani, Anggara Lomak Prihatin, Adim Hadi, Surat Indrijarso, Priyambodo Rahardjo, Arief Barkah, Irhan Febijanto, Nugroho Adi Sasongko   +19 more
doaj   +1 more source

Rethinking the institutional mapping of Iran's national innovation system; A new typology based on knowledge functions [PDF]

مدیریت راهبردی دانش سازمانی
Purpose: The national innovation system is a kind of systemic approach to innovation and includes elements and components that interact with each other to produce, disseminate, and use new and economically beneficial knowledge and operate within the ...
Payam Haghighi Boroujeni, Mostafa Safdari Ranjbar, Toraj Karimi, Seyed Mohammadbagher Jafari   +3 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Macroeconomic and taxation conditions of national innovation system of Ukraine [PDF]

NIS is nowadays one of the most widespread tools of the analysis of factors influencing the creation, diffusion and adoption of innovations. Innovation is often more seen as the main driver for growth within economic and social systems. During the Soviet
Dimitri Gagliardi, Andrey Martovoy
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