Results 61 to 70 of about 606,689 (307)

Aspects of Properly-Functioning National Innovation System: The Case of Latvia [PDF]

Societas et Iurisprudentia, 2013
Innovation support policies should take into consideration all particular qualities of national innovation system in the country, not being one-size-fits-all, in this case, the analysis of strengths and weaknesses of national innovation system is ...
Daina Šķiltere, Svetlana Jesiļevska
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Experiences and user perceptions of virtual-reality-based mindfulness interventions: protocol for a systematic review and thematic synthesis

BMJ Open
Introduction Virtual reality (VR) technology is increasingly being explored as a medium for delivering mindfulness-based interventions. While studies have investigated the feasibility and efficacy of VR-based mindfulness interventions, there has been ...
Amartya Mukhopadhyay, Amanda Yap, Ravi Shankar, Anjali Bundele   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Macroeconomic and taxation conditions of national innovation system of Ukraine [PDF]

NIS is nowadays one of the most widespread tools of the analysis of factors influencing the creation, diffusion and adoption of innovations. Innovation is often more seen as the main driver for growth within economic and social systems. During the Soviet
Dimitri Gagliardi, Andrey Martovoy
core  

Rethinking the institutional mapping of Iran's national innovation system; A new typology based on knowledge functions [PDF]

مدیریت راهبردی دانش سازمانی
Purpose: The national innovation system is a kind of systemic approach to innovation and includes elements and components that interact with each other to produce, disseminate, and use new and economically beneficial knowledge and operate within the ...
Payam Haghighi Boroujeni, Mostafa Safdari Ranjbar, Toraj Karimi, Seyed Mohammadbagher Jafari   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thaksin’s Legacy: Thaksinomics and Its Impact on Thailand’s National Innovation System and Industrial Upgrading [PDF]

Thaksin Shinawatra was one of the most powerful prime ministers of Thailand. Undergirded by a set of new policies termed Thaksinomics, great political power, his CEO style of management, and his intention to make Thailand a developed country, his ...
Patarapong Intarakumnerd
core  

Current scenario and potential of waste cooking oil as a feedstock for biodiesel production in Indonesia: Life cycle sustainability assessment (LCSA) review

Case Studies in Chemical and Environmental Engineering
WCO is a second-generation biofuel made up of accumulated free fatty acids, which can be used as feedstock for biodiesel production. The review aims to: (a) evaluate the sustainability of waste cooking oil (WCO) for biodiesel production in Indonesia ...
Arif Rahman, M.A.M. Oktaufik, Triyono Widi Sasongko, Iwan Guntoro, Dadi Soedjati, Najmi Abbas, Abdul Rahman, Fathiah Ulfah, Ari Widiarto, Siswanto, Dharmawan, Sudarwaji Edi Yuwono Trihadi, Kusrestuwardani, Anggara Lomak Prihatin, Adim Hadi, Surat Indrijarso, Priyambodo Rahardjo, Arief Barkah, Irhan Febijanto, Nugroho Adi Sasongko   +19 more
doaj   +1 more source

National innovation system as a focus of state in-novation policy [PDF]

International Economic Policy, 2007
The article offers a systematic review of tools and mechanisms utilised by developed countries (United States, Japan, EU) to pursue their innovation policies, and classifies methods which support innovation and ways that help to strengthen the innovation
Olexandr Fedirko
doaj