Results 111 to 120 of about 1,345,097 (304)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

PublicationHarvester: An Open-Source Software Tool for Science Policy Research [PDF]

We present PublicationHarvester, an open-source software tool for gathering publication information on individual life scientists. The software interfaces with MEDLINE, and allows the end-user to specify up to four MEDLINE-formatted names for each ...
Andrew Stellman, Joshua Graff Zivin, Pierre Azoulay   +2 more
core  

Gene gain and loss push prokaryotes beyond the homologous recombination barrier and accelerate genome sequence divergence

Nature Communications, 2019
A significant proportion of the molecular evolution of bacteria and archaea occurs through gene gain and loss. Here Iranzo et al. develop a mathematical model that explains observed differential patterns of sequence evolution vs.
Jaime Iranzo, Yuri I. Wolf, Eugene V. Koonin, Itamar Sela   +3 more
doaj   +1 more source

The multiple dimensions of expanded access to health information: Don Lindberg and the U.S. National Library of Medicine. [PDF]

Inf Serv Use, 2022
Humphreys BL.
europepmc   +1 more source

Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov, Alexander F. Santillo, Patrick R. Hof   +2 more
wiley   +1 more source

Large-scale predictions of alternative protein conformations by AlphaFold2-based sequence association

Nature Communications
The many successes of AlphaFold2 (AF2) have inspired methods to predict multiple protein conformations, many of which have biological significance.
Myeongsang Lee, Joseph W. Schafer, Jeshuwin Prabakaran, Devlina Chakravarty, Madeleine F. Clore, Lauren L. Porter   +5 more
doaj   +1 more source

History with Heart-and Impact: The National Library of Medicine Michael E. DeBakey Fellowship in the History of Medicine. [PDF]

Methodist Debakey Cardiovasc J, 2021
Reznick JS, Koyle KM.
europepmc   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Data policy and availability supporting global change research, development, and decision-making: An information perspective [PDF]

An explosion of information has created a crisis for today's information age. It has to be determined how to use the best available information sources, tools, and technology.
Carroll, Bonnie C., Cotter, Gladys A., Jack, Robert F.   +2 more
core   +1 more source

Corrigendum to: The roles of the US National Library of Medicine and Donald A.B. Lindberg in revolutionizing biomedical and health informatics. [PDF]

J Am Med Inform Assoc, 2022
Miller RA, Shortliffe EH.
europepmc   +1 more source