Results 41 to 50 of about 1,345,097 (304)

The Impact Of Federal Legislation On Governmental And Special Libraries [PDF]

open access: yes, 1966
It has become increasingly obvious that libraries today cannot provide adequate service under conditions of local self-sufficiency. A variety of programs are required on the national level which cannot be provided by individual libraries or ...
Skipper, James E.
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The medical science DMZ: a network design pattern for data-intensive medical science [PDF]

open access: yes, 2017
: Objective We describe a detailed solution for maintaining high-capacity, data-intensive network flows (eg, 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and regulations. Materials and Methods
Balas, Edward   +8 more
core   +1 more source

A graphical user interface for RAId, a knowledge integrated proteomics analysis suite with accurate statistics

open access: yesBMC Research Notes, 2018
Objective RAId is a software package that has been actively developed for the past 10 years for computationally and visually analyzing MS/MS data. Founded on rigorous statistical methods, RAId’s core program computes accurate E-values for peptides and ...
Brendan Joyce   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Deep learning with sentence embeddings pre-trained on biomedical corpora improves the performance of finding similar sentences in electronic medical records

open access: yesBMC Medical Informatics and Decision Making, 2020
Background Capturing sentence semantics plays a vital role in a range of text mining applications. Despite continuous efforts on the development of related datasets and models in the general domain, both datasets and models are limited in biomedical and ...
Qingyu Chen   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Ranking Medical Subject Headings using a factor graph model. [PDF]

open access: yes, 2015
Automatically assigning MeSH (Medical Subject Headings) to articles is an active research topic. Recent work demonstrated the feasibility of improving the existing automated Medical Text Indexer (MTI) system, developed at the National Library of Medicine
Demner-Fushman, Dina   +4 more
core  

Comparative Evaluation of Websites of United States National Library of Medicine and Iranian National Library of Medicine

open access: yesمدیریت اطلاعات سلامت, 2013
Introduction: Nowadays and with the increasing role of the worldwide web as one of the most important sources of information on the one hand, and the enhancement of its usability on the other, it is necessary for the web designers and developers to be ...
Sedigheh Mohammadesmaeil   +1 more
doaj  

Semantic annotation of consumer health questions

open access: yesBMC Bioinformatics, 2018
Background Consumers increasingly use online resources for their health information needs. While current search engines can address these needs to some extent, they generally do not take into account that most health information needs are complex and can
Halil Kilicoglu   +6 more
doaj   +1 more source

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