Results 71 to 80 of about 2,055,123 (266)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

The Existence of Mortality in the Russian-language Prose of Contemporary Tatar Writers

open access: yesPolylinguality and Transcultural Practices
The study is devoted to the consideration of the existence of mortality in the works of contemporary Russian-speaking Tatar writers (Salavat Yuzeev, Rustem Sabirov, Shamil Idiatullin, Albina Nurislamova, Guzel Yakhina), on the one hand, influencing the ...
Diana Yu. Syryseva
doaj   +1 more source

La ‘mutilation anthropologique’ et le réalignement de la littérature camerounaise Cilas Kemedjio

open access: yesTydskrif vir Letterkunde, 2016
‘Anthropological mutilation’ and the reordering of Cameroonian literature. I argue in this article that the postcolonial existential wound, otherwise referred to by Eboussi Boulaga as the anthropological mutilation, represents the intertextual nexus that
Cilas Kemedjio
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

O narrador e a paisagem: Milton Hatoum, Bernardo Carvalho e o fim do projeto de uma literatura nacional

open access: yesEstudos de Literatura Brasileira Contemporânea, 2015
In this paper, we discuss the end of the project of a national literature a s a guiding project of the Brazilian novel, having in mind the changes in the construction of the narrator and the representation of ...
Pedro Dolabela Chagas   +1 more
doaj  

Exploring the relationship between the eighteen character values in Indonesian National identity and East Borneo folklore

open access: yesCogent Arts & Humanities
The article focuses on mapping resonance between folklore narratives and the 18 character values adopted by the government of Indonesia, with the potential to facilitate integration in the New National Capital City.
Riani Riani   +8 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Stakeholder Engagement in the Development of the General Education Curriculum for Language Arts and Literature in Vietnam (2022-2025)

open access: yesVietnam Journal of Education
Curriculum development is a complex process that requires the coordinated participation of various stakeholders both inside and outside of the school.
Hai Anh Doan   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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