Results 71 to 80 of about 2,960,747 (312)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Migrant Voices in the Plurilingual Poetry and Creative Practice of Fióna Bolger

open access: yesELOPE
This article investigates the responses of Irish contemporary poetry to transnational migration and the attempts of poets to build empathetic connections with migrants and refugees, who face increasing violence across the European continent and beyond ...
Aneta Stępień
doaj   +1 more source

From ‘national’ literature to multicultural literature in ‘Japanese’ language? [PDF]

open access: yes, 2017
This chapter offers a genealogy of Japanese literary studies, with a special focus on the two terms that have been most commonly used to denote Japanese literature and literary studies in Japan since the early 20th century: kokubungaku (national literature and its study) and nihon bungaku (Japanese literature).
openaire   +4 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

La literatura cubana a partir de 1923. Defensa de la identidad nacional/Cuban literature since 1923. Defense of the national identity

open access: yesPedagogía y Sociedad
Cuba se convirtió a lo largo del tiempo en hogar de diversos componentes étnicos que llegaron indistintamente y fueron permitiendo un interactuar de culturas y lenguas. En medio de este contexto, se va gestando un proceso transculturativo, para dar lugar
Yamile Fortunata Arrieta-Rodríguez   +2 more
doaj  

‘Anthropological mutilation’ and the reordering of Cameroonian literature

open access: yesTydskrif vir Letterkunde, 2016
I argue in this article that the postcolonial existential wound, otherwise referred to by Eboussi Boulaga as the anthropological mutilation, represents the intertextual nexus that bridges the generational gap in Francophone Cameroonian literature.
Cilas Kemedjio
doaj   +1 more source

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