Results 71 to 80 of about 20,538,929 (301)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

DATA ON ARTS ORGANIZATIONS: A REVIEW AND NEEDS ASSESSMENT, WITH DESIGN IMPLICATIONS [PDF]

open access: yes
This project describes the data resources on arts organizations that are currently available to inform the efforts of policy makers, arts managers, and researchers working in the arts field.
Lori Morris   +3 more
core  

Texas National Security Review: Rethink, Reframe, Re-examine Vol. 8, Issue 3, 2025 [PDF]

open access: yes
TABLE OF CONTENTS: The Foundation pg.2 When Conventional Wisdom Fails Sheena Chestnut Greitens The Scholar pg.8 Lost Seoul? Assessing Pyongyang’s Other Deterrent Nicholas D. Anderson and Daryl G. Press pg.28 So What?
Texas National Security Review
core   +1 more source

Sanitary Organization of Nations [PDF]

open access: yesThe Boston Medical and Surgical Journal, 1880
n ...
openaire   +2 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Leadership Policy and Organization 3465 2009 - Macro-Brain Drain-Group 5

open access: yes, 2009
Includes descriptive metadata provided by producer in M4V file: "Leading Globally Diverse Organizations - Macro: Across Nat'l - Macro-Brain Drain-Group 5." By Vanderbilt University. This presentation for the course Leadership in Organizations discusses
Leadership Policy and Organizations
core  

Clubs and Organizations - 1941 - United Service Organizations Card [PDF]

open access: yes, 1941
United Service Organizations Card of Madge Webb Rileyhttps://digitalcommons.gardner-webb.edu/fay-webb-gardner-madge-webb-riley/1030/thumbnail ...
United Service Organizations,
core  

CONCERNING THE ISSUE OF DEVELOPING A STRATEGIC TOOLKIT FOR THE HARMONIOUS DEVELOPMENT OF TOURISM AND HOTEL-RESTAURANT ENTERPRISES

open access: yesФінансово-кредитна діяльність: проблеми теорії та практики
The literature review shows that, at the national level, developing a strategic toolkit for harmonious development, including for tourism and hotel-restaurant enterprises, is still at an early stage.
Тетяна Кулініч   +4 more
doaj   +1 more source

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