Results 151 to 160 of about 35,157 (248)

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

CACLENS: A Multitask Deep Learning System for Enzyme Discovery

Advanced Science, Volume 13, Issue 9, 13 February 2026.
CACLENS, a multimodal and multi‐task deep learning framework integrating cross‐attention, contrastive learning, and customized gate control, enables reaction type classification, EC number prediction, and reaction feasibility assessment. CACLENS accelerates functional enzyme discovery and identifies efficient Zearalenone (ZEN)‐degrading enzymes.
Xilong Yi, Yingzhu Tan, Huikang Lin, Guoqing Zhang, Ye Tian, Aibo Wu   +5 more
wiley   +1 more source

Clinically Irrelevant Terminal 16q21 Deletion Detected by NIPT Is Attributable to Inherited Fragility at FRA16B

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 348-352, February 2026.
ABSTRACT Genome‐wide non‐invasive prenatal testing (NIPT) is a powerful tool for prenatal detection of the common aneuploidies causing Down‐, Edwards‐, and Patau syndrome. Its genome‐wide reach also enables the detection of unbalanced structural chromosomal abnormalities.
Servi J. C. Stevens, Wanwisa van Dijk, Nicole Y. Souren, Merryn V. E. Macville, Guillaume van de Zande, Brigitte H. W. Faas, Bart de Koning, Arthur van den Wijngaard, Sonja de Munnik, Masoud Zamani Esteki   +9 more
wiley   +1 more source

Synthesis of Indolocarbazole‐Diketopyrrolopyrrole Dyads and Investigation of Their Photoinduced Electron Transfer Properties

Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.
Three ICZ‐DPP dyads are synthesized using the Suzuki–Miyaura cross‐coupling reaction as a key step. Photophysical studies of the dyads showed broad and strong visible light absorption, and ultrafast electron transfer from ICZ donor to DPP acceptor, leading to charge separated state in polar solvents.
Richa Agrawal, Mrunesh Koli, Manoj K. Choudhary, Sudip Gorai, Rajib Ghosh, Soumyaditya Mula   +5 more
wiley   +1 more source

Mechanochromic Organic Materials: Molecular Mechanisms and Multidimensional Applications

Advanced Physics Research, Volume 5, Issue 2, February 2026.
Mechanochromic (MC) organic materials change color in response to mechanical force. This review elucidates the molecular mechanisms (e.g., aggregation‐induced emission, AIE) and explores their multidimensional applications in sensors, anti‐counterfeiting, biomedical devices, and structural health monitoring, providing a roadmap for future smart ...
Xiaozhe Yin, Guoliang Niu, Yu Wang, Angela Wittmann, Huiyang Gou, Lang Jiang   +5 more
wiley   +1 more source

Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity

Archiv der Pharmazie, Volume 359, Issue 2, February 2026.
We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...
Abdul Aziz Timbilla, Filip Pidany, Eliska Kohelova, Jana Kroustkova, Karel Kralovec, Jan Rataj, Martina Ceckova, Negar Maafi, Víctor Lopez, Cristina Moliner Langa, Stefan Kosturko, Jaroslav Jenco, Darina Muthna, Darja Koutova, Martina Rezacova, Lucie Cahlikova, Jakub Chlebek, Radim Havelek   +17 more
wiley   +1 more source

Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
UL induced significant spatial and non‐spatial cognitive dysfunction and hippocampal neurogenesis inhibition, whereas aerobic exercise intervention effectively reversed these impairments. Transcriptomic profiling and pharmacological evidence identified MHC class I/II–related pathways (H2‐K1, H2‐Eb1, CD74) as key mediators of the restorative effects of ...
Zhanghong Zhou, Xixi Yu, E. Tian, Zhaoqi Guo, Jingyu Chen, Jiaqi Guo, Shiyu Shi, Wandi Xu, Ni Zhai, Caijuan Qiao, Yuejin Zhang, Jun Wang, Yisheng Lu, Sulin Zhang   +13 more
wiley   +1 more source

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Matthieu Leuillier, Mustapha Chelgham, Hind Messaoudi, Ly Tu, Severine Ménoret, Raphaël Thuillet, Déborah Groussard, Felix F. Lillich, Mina Ottaviani, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Ignacio Anegon, Christophe Morisseau, Ewgenij Proschak, Christophe Guignabert, Jérémy Bellien   +17 more
wiley   +1 more source

Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Despite the remarkable versatility of enzymes for catalyzing complex organic transformations under mild aqueous conditions, no biocatalytic system has been reported for intermolecular C–H fluorination. A radical photoenzymatic approach is introduced that leverages a designed de novo protein scaffold with an unnatural amino acid to achieve precise ...
Yu Zhou, Danielle Lawson, Zihan Zhang, Yunling Deng, Hejun Deng, Connor J. O'Dea, Zachariah A. Page, Yi Lu   +7 more
wiley   +2 more sources

A Green, Facile Method for Selective α‑Bromination of Flavanones. [PDF]

ACS Omega
Sigmon AJ, Laremore TN, Yennawar H, Guerin GC, Pelletier B, Dallal S, Aggroia S, Englert M, George C.   +8 more
europepmc   +1 more source