Results 91 to 100 of about 18,734,905 (244)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

The origins and development of the Scottish Parliament, 1249-1329 [PDF]

, 2015
This thesis examines the origins and development of Scottish parliaments between 1124 and 1329. Previous historians have judged that parliaments formed no place within Scotland before 1290 and no frequent roIe until the reign of Robert I.
McQueen, Alison A.B.
core   +2 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

The Behaviour of Political Parties and MPs in the Parliaments of the Weimar Republic [PDF]

, 2011
Analysing the roll call votes of the MPs of the Weimar republic we find that 1) party competition in the Weimar parliaments can be structured on two dimensions: a left-right and a pro-/antidemocratic dimension.
Hansen, Martin Ejnar, Debus, Marc, Martin Ejnar Hansen, Marc Debus, Hansen, ME, Debus, M   +5 more
core   +1 more source

Crise: la sortie par le haut, c’est l’Europe [PDF]

Romanian Journal of European Affairs, 2010
The crisis is not the root cause of the collapse of the European Union’s economy; it is its revealing sign. The protectionism temptation has not been overcome at the European level, and yet Europe is the right path towards overcoming the crisis.
Alain Lamassoure
doaj  

Brexit under Scrutiny in EU Member States: What Role for National Parliaments in Austria and Germany?

Politics and Governance, 2019
Among national parliaments (NPs) in the EU, the Austrian Nationalrat and the German Bundestag stand out as strong legislatures in EU affairs. Both parliaments have used their rights to great extent in recent EU negotiations on international agreements ...
Katharina Luise Meissner
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

"The timing of EU membership and its effect on national legislative oversight of European affairs" [PDF]

, 2007
This paper explores the effects of European integration on national level legislatures in European Union member states. Many economic and political decisions previously made by democratically elected national legislatures are now decided at a ...
Hamerly, Ivy.
core  

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source