Results 71 to 80 of about 71,841 (312)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

La asamblea de Extremadura y el control del principio de subsidiariedad a través del mecanismo de alerta temprana [PDF]

Revista d'Estudis Autonòmics i Federals, 2011
This paper analyzes the participation of the Spanish regional Parliaments,specially the Assembly of Extremadura, in the early warning system for monitoringthe application of the principle of subsidiarity, in order to know ifthis participation helps to ...
José Ángel Camisón Yagüe
doaj  

Relations between national parliaments and the European Parliament: opportunities and challenges [PDF]

, 2011
This paper provides an insight into how interparliamentary cooperation between national parliaments and the EP is evolving, what forms it is taking and what its main advantages and flaws are.
Ruiz de Garibay, Daniel
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The Parliamentary Legitimacy of the European Union: The Role of the States General within the European Union

Utrecht Law Review, 2012
This article presents the state of play in the Netherlands with regard to parliamentary scrutiny in EU decision-making. Although the States General have all in all dealt with EU decision-making fairly actively, this contribution makes clear that ...
Leonard F.M. Besselink, Brecht van Mourik   +1 more
doaj   +1 more source

THE LISBON TREATY- LINK BETWEEN PARTICIPATIVE DEMOCRACY AND ADMINISTRATIVE MODERNIZATION [PDF]

This paperwork examines briefly, the implications it carries on the Lisbon Treaty, the organizational, institutional and decision-making level in the current context of the European Union, included in the reform process.
Bosie Irina, Onofrei Mihaela
core  

Parliamentary functions portrayed on European parliaments' websites [PDF]

, 2009
This article uses data from a pilot study on the websites of 15 parliaments in Europe to identify which parliamentary functions are portrayed on these websites.
Leston-Bandeira, Cristina
core   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Methodological Reflections on Studying Gender‐Sensitive Parliaments Cross‐Nationally: A “Most Significant Change” Approach

Politics and Governance
Whilst cross-national comparative analyses provide distinct opportunities for the study of gender-sensitive parliaments, the inherent challenge in conducting comparisons necessitates a continued search for innovative methods.
Petra Ahrens, Silvia Erzeel, Merel Fieremans   +2 more
doaj   +1 more source

Values Topple Nationality in the European Parliament [PDF]

European View, 2015
This article shows that the internal unity of EU political groups, the legislative arm of the EU-level parties, is surprisingly high, despite the increasing cultural and geographical diversity among member states as a result of successive EU enlargements. Members of the European Parliament come from 28 countries with very different economic situations,
openaire   +1 more source