Results 71 to 80 of about 18,734,905 (244)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

The Parliamentary Legitimacy of the European Union: The Role of the States General within the European Union

open access: yesUtrecht Law Review, 2012
This article presents the state of play in the Netherlands with regard to parliamentary scrutiny in EU decision-making. Although the States General have all in all dealt with EU decision-making fairly actively, this contribution makes clear that ...
Leonard F.M. Besselink   +1 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

The Barroso Initiative: Window Dressing or Democracy Boost?

open access: yesUtrecht Law Review, 2012
This article carries out a multifaceted legal analysis of the so-called Barroso Initiative, which was commenced by the European Commission in September 2006 in order to involve national parliaments of the Member States in the process of EU policy making.
Davor Jančić
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

La asamblea de Extremadura y el control del principio de subsidiariedad a través del mecanismo de alerta temprana [PDF]

open access: yesRevista d'Estudis Autonòmics i Federals, 2011
This paper analyzes the participation of the Spanish regional Parliaments,specially the Assembly of Extremadura, in the early warning system for monitoringthe application of the principle of subsidiarity, in order to know ifthis participation helps to ...
José Ángel Camisón Yagüe
doaj  

The Crown and Parliament. The Tragic Fates of English King Charles I and Russian Tsar Nicholas II: a Comparative Study

open access: yesCzasopismo Prawno-Historyczne, 2009
This paper examines a very acute problem – the relationships between crowns and their parliaments in history as personified by two political figures: English King Charles I and Russian Tsar Nicholas II. In spite of the three centuries which divide these
Izmail Sharifzhanov
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source

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