Results 81 to 90 of about 71,841 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Los parlamentos regionales y el mecanismo de alerta temprana (su aplicación en el Parlamento Vasco)

Revista Vasca de Administración Pública, 2012
The Treaty of Lisbon confers Regional Parliaments the possibility of participating in the control of the principle of subsidiarity by means of early-warning mechanism. However, the participation of Regional parliaments depends on the real function of the
Maribel González Pascual
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Role of national parliaments [PDF]

, 2014
Presentation to the Conference on the long-term future of the European Court of Human Rights, organised by PluriCourts and the Council of Europe in Oslo, 7-8 April 2014. The presentation discusses the role of parliaments in the implementation of judgments of the European Court of Human Rights.
Donald, Alice, PluriCourts and the Council of Europe   +1 more
openaire  

Nuclear weapons and European interests : Discussions in the Assembly of the Western European Union, 1955–1975 [PDF]

, 2011
In the 1950s and 1960s the Defence Committee of the Western European Union (WEU) Assembly submitted a series of conspicuous reports on nuclear control issues, culminating in a plea for an Atlantic nuclear force.
Megens, C.M,
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Eurosceptics into the Limelight? Eurosceptic Parliamentary Actors and Media Bias in EU Affairs

Politics and Governance, 2019
In the spotlight for some time now, the potential of national parliaments to legitimise EU politics has become even more salient given the growing politicisation and public contestation of EU issues.
Katrin Auel
doaj   +1 more source

What Happens in Parliament Stays in Parliament? Newspaper Coverage of National Parliaments in EU Affairs

JCMS: Journal of Common Market Studies, 2017
AbstractThe role of national parliaments in EU matters has become an important subject in the debate over the democratic legitimacy of the European Union. Yet despite a remarkable increase in parliamentary involvement in EU affairs, the added value in terms of democratic legitimacy will remain limited if citizens are not aware of their activities ...
Auel, Katrin, Eisele, Olga, Kinski, Lucy
openaire   +3 more sources

Why the European Parliament has a better gender balance than national parliaments [PDF]

, 2015
Across Europe there is a wide variation in the percentage of female representatives in national parliaments, with the gender balance typically skewed toward male representatives.
Fortin-Rittberger, Jessica, Rittberger, Berthold   +1 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source