Results 81 to 90 of about 4,538,204 (341)

National parliaments and the policing of the subsidiarity principle [PDF]

open access: yes, 2014
Defence date: 16 December 2014Examining Board: Professor Bruno De Witte, European University Institute (Supervisor); Professor Loïc Azoulai, European University Institute; Professor Damian Chalmers, London School of Economics; Professor Thomas ...
GRANAT, Katarzyna
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

The Parliamentary Legitimacy of the European Union: The Role of the States General within the European Union

open access: yesUtrecht Law Review, 2012
This article presents the state of play in the Netherlands with regard to parliamentary scrutiny in EU decision-making. Although the States General have all in all dealt with EU decision-making fairly actively, this contribution makes clear that ...
Leonard F.M. Besselink   +1 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Values Topple Nationality in the European Parliament [PDF]

open access: yesEuropean View, 2015
This article shows that the internal unity of EU political groups, the legislative arm of the EU-level parties, is surprisingly high, despite the increasing cultural and geographical diversity among member states as a result of successive EU enlargements. Members of the European Parliament come from 28 countries with very different economic situations,
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Parliamentary scrutiny of EU law proposals in Denmark: why do governments request a negotiation mandate? IHS Political Science Series No. 127, February 2012 [PDF]

open access: yes, 2012
Political scientists have been concerned about the loss of power of national parliaments through the shift of competences to the EU level. In this respect the Danish system of parliamentary scrutiny has been recommended as being highly effective. In this
Melzer, Marius, Finke, Daniel
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Relationship between National Parliaments and the European Union [PDF]

open access: yes, 2015
Dissertation thesis "Relationship between National Parliaments and the European Union" examines the impacts of the European integration on the national parliaments - the limitation of their functions and powers, measures undertaken to compensate these ...
Grinc, Jan
core  

Los parlamentos regionales y el mecanismo de alerta temprana (su aplicación en el Parlamento Vasco)

open access: yesRevista Vasca de Administración Pública, 2012
The Treaty of Lisbon confers Regional Parliaments the possibility of participating in the control of the principle of subsidiarity by means of early-warning mechanism. However, the participation of Regional parliaments depends on the real function of the
Maribel González Pascual
doaj   +1 more source

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