Results 11 to 20 of about 21,560 (287)

Intrarenal Mechanisms of Sodium-Glucose Cotransporter-2 Inhibitors on Tubuloglomerular Feedback and Natriuresis [PDF]

open access: yesEndocrinology and Metabolism, 2023
When sodium-glucose cotransporter-2 (SGLT2) inhibitors were first introduced a decade ago, no one expected them to have substantial effects beyond their known glucose-lowering effects, until the emergence of evidence of their robust renal and ...
Eun Sil Koh, Gheun-Ho Kim, Sungjin Chung
doaj   +1 more source

Natriuresis-guided diuretic therapy in acute heart failure: a pragmatic randomized trial

open access: yesNature Medicine, 2023
In patients with acute heart failure, personalized dosing of a diuretic led to treatment intensification in the majority of patients and improved natriuresis, but had no effects on time to all-cause mortality or heart failure rehospitalization ...
J. T. ter Maaten   +9 more
semanticscholar   +1 more source

Natriuresis‐guided therapy in acute heart failure: rationale and design of the Pragmatic Urinary Sodium‐based treatment algoritHm in Acute Heart Failure (PUSH‐AHF) trial

open access: yesEuropean Journal of Heart Failure, 2021
Insufficient diuretic response frequently occurs in patients admitted for acute heart failure (HF) and is associated with worse clinical outcomes. Recent studies have shown that measuring natriuresis early after hospital admission could reliably identify
J. T. ter Maaten   +8 more
semanticscholar   +1 more source

Acclimation to a High‐Salt Diet Is Sex Dependent

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Premenopausal women are less likely to develop hypertension and salt‐related complications than are men, yet the impact of sex on mechanisms regulating Na+ homeostasis during dietary salt challenges is poorly defined.
Eman Y. Gohar   +14 more
doaj   +1 more source

Current Understanding of Pressure Natriuresis

open access: yesElectrolytes & Blood Pressure, 2021
Pressure natriuresis refers to the concept that increased renal perfusion pressure leads to a decrease in tubular reabsorption of sodium and an increased sodium excretion.
E. Baek, Sejoong Kim
semanticscholar   +1 more source

Effects of Nifedipine on Renal and Cardiovascular Responses to Neuropeptide Y in Anesthetized Rats

open access: yesMolecules, 2021
Neuropeptide Y (NPY) acts via multiple receptor subtypes termed Y1, Y2 and Y5. While Y1 receptor-mediated effects, e.g., in the vasculature, are often sensitive to inhibitors of L-type Ca2+ channels such as nifedipine, little is known about the role of ...
Angela Bischoff   +2 more
doaj   +1 more source

Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses

open access: yesJournal of Veterinary Internal Medicine, 2023
Background Treatment with phenylbutazone (nonselective COX inhibitor) decreases the diuretic and natriuretic effects of furosemide by nearly 30% but the effects of COX‐2 specific inhibitors (firocoxib) and atypical NSAIDs (dipyrone) are unknown ...
Julianne M. White   +2 more
doaj   +1 more source

Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart FailurePlain-Language Summary

open access: yesKidney Medicine, 2022
Rationale & Objective: Heart failure treatment relies on loop diuretics to induce natriuresis and decongestion, but the therapy is often limited by diuretic resistance.
Jonathan G. Amatruda   +6 more
doaj   +1 more source

Sex-Specific Computational Models of Kidney Function in Patients With Diabetes

open access: yesFrontiers in Physiology, 2022
The kidney plays an essential role in homeostasis, accomplished through the regulation of pH, electrolytes and fluids, by the building blocks of the kidney, the nephrons.
Sangita Swapnasrita   +3 more
doaj   +1 more source

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