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High Blood Pressure & Cardiovascular Prevention, 2005
natriuretic effects. They were first identified in 1981 by the pivotal work of de Bold and colleagues. In the 25 years elapsed since the initial discovery, an impressive amount of research has been carried out to identify the structure of the active peptide and its receptors, to characterise the biological functions of these molecules and their ...
Vito M. Campese, Mitra K. Nadim
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natriuretic effects. They were first identified in 1981 by the pivotal work of de Bold and colleagues. In the 25 years elapsed since the initial discovery, an impressive amount of research has been carried out to identify the structure of the active peptide and its receptors, to characterise the biological functions of these molecules and their ...
Vito M. Campese, Mitra K. Nadim
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Basic Research in Cardiology, 2004
The natriuretic peptides are a family of widely distributed, but evolutionarily conserved, polypeptide mediators that exert a range of actions throughout the body. In cardiovascular homeostasis, the endocrine roles of the cardiac-derived atrial and B-type natriuretic peptide (ANP and BNP) in regulating central fluid volume and blood pressure have been ...
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The natriuretic peptides are a family of widely distributed, but evolutionarily conserved, polypeptide mediators that exert a range of actions throughout the body. In cardiovascular homeostasis, the endocrine roles of the cardiac-derived atrial and B-type natriuretic peptide (ANP and BNP) in regulating central fluid volume and blood pressure have been ...
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Current Opinion in Cardiology, 1986
Publisher Summary The natriuretic peptide system consists of three peptides with similar structures. These peptides cause a wide range of actions in the kidney, the vasculature, the heart, and the central nervous system. Atrial natriuretic peptide (ANP) has subsequently been the subject of extensive investigation.
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Publisher Summary The natriuretic peptide system consists of three peptides with similar structures. These peptides cause a wide range of actions in the kidney, the vasculature, the heart, and the central nervous system. Atrial natriuretic peptide (ANP) has subsequently been the subject of extensive investigation.
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Comprehensive Physiology, 1999
Abstract The sections in this article are: Historical Perspectives Primary Structure Assay Methods The Endocrine Heart
Adolfo J. De Bold, Benoit G. Bruneau
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Abstract The sections in this article are: Historical Perspectives Primary Structure Assay Methods The Endocrine Heart
Adolfo J. De Bold, Benoit G. Bruneau
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Over the last four decades, cardiac natriuretic peptides have changed our understanding of patients with chronic heart failure. From the discovery of the heart as an endocrine organ with its own hormones and receptors, the biochemistry and physiology of the system have been translated into useful biomarkers and drug targets in cardiovascular disease ...
Theodor W, Shalmi +2 more
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Theodor W, Shalmi +2 more
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Physiology of Natriuretic Peptides
Journal of Internal Medicine, 1994De Bold’s discovery 16 yr ago of an atrial tissue factor (1) with strong natriuretic activity understandably captured the imagination of renal physiologists seeking the elusive “third factor” (2) and new insights into sodium regulation. However, as well as natriuresis, de Bold’s original experiments showed that the atrial extract also caused ...
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