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The natriuretic peptide family
Current Opinion in Nephrology and Hypertension, 1993The natriuretic peptide system is a complicated system comprising at least three endogenous peptides (atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide) and three receptors [the atrial natriuretic peptide-A receptor (guanylyl cyclase A), the atrial natriuretic peptide-B receptor (guanylyl cyclase B) and the clearance ...
K, Nakao +4 more
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Physiology of Natriuretic Peptides
Journal of Internal Medicine, 1994De Bold’s discovery 16 yr ago of an atrial tissue factor (1) with strong natriuretic activity understandably captured the imagination of renal physiologists seeking the elusive “third factor” (2) and new insights into sodium regulation. However, as well as natriuresis, de Bold’s original experiments showed that the atrial extract also caused ...
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Natriuretic peptides and hypertension
Current Opinion in Nephrology and Hypertension, 1996Natriuretic peptides are produced in the brain, heart and vasculature, and cause vasodilation, sodium excretion, and diuresis. Recent advances indicate that they play important roles in blood-pressure homeostasis, both in normal and in pathophysiological conditions.
B A, Prins, E, Biesiada, E R, Levin
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The natriuretic peptides in hypertension
Current Opinion in CARDIOLOGY, 1995The natriuretic peptide family consists of three members: atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Atrial and brain natriuretic peptides possess similar effects, causing natriuresis, vasodilation, and suppression of the renin-angiotensin-aldosterone system.
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The natriuretic-peptide family
The Lancet, 1997The discovery in the early 1980s of atrial natriuretic peptide, a circulating peptide with natriuretic/diuretic and vasorelaxant properties was greeted with excitement since the existence of a humoral link between heart and kidney had long been predicted.
M R, Wilkins, J, Redondo, L A, Brown
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The Natriuretic Peptides for Hypertension Treatment
High Blood Pressure & Cardiovascular Prevention, 2021Hypertension is a common pathological condition predisposing to a higher occurrence of cardiovascular diseases and events. Unfortunately, treatment of hypertension is still suboptimal worldwide. More efforts are needed to implement the availability of anti-hypertensive drugs.
Rubattu S., Gallo G.
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Biology of the Natriuretic Peptides
The American Journal of Cardiology, 2008The biology of the natriuretic peptide (NP) system is complex, yet highly phylogenetically preserved. It regulates salt and water handling, promotes vasodilatation, and exerts favorable effects on the heart in the context of processes such as heart failure.
Abelardo, Martinez-Rumayor +3 more
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Current Opinion in Cardiology, 1986
Publisher Summary The natriuretic peptide system consists of three peptides with similar structures. These peptides cause a wide range of actions in the kidney, the vasculature, the heart, and the central nervous system. Atrial natriuretic peptide (ANP) has subsequently been the subject of extensive investigation.
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Publisher Summary The natriuretic peptide system consists of three peptides with similar structures. These peptides cause a wide range of actions in the kidney, the vasculature, the heart, and the central nervous system. Atrial natriuretic peptide (ANP) has subsequently been the subject of extensive investigation.
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Journal of Cardiothoracic Anesthesia, 1989
This report has reviewed some of the cardiovascular aspects of ANP. The emergence of the heart as an endocrine organ requires that numerous questions be asked with regard to the importance of ANP to anesthesia and surgery. It is clear that the interaction of the hormone with other vasoactive compounds, including anesthetic agents, requires further ...
R W, McIntyre, D A, Schwinn
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This report has reviewed some of the cardiovascular aspects of ANP. The emergence of the heart as an endocrine organ requires that numerous questions be asked with regard to the importance of ANP to anesthesia and surgery. It is clear that the interaction of the hormone with other vasoactive compounds, including anesthetic agents, requires further ...
R W, McIntyre, D A, Schwinn
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Over the last four decades, cardiac natriuretic peptides have changed our understanding of patients with chronic heart failure. From the discovery of the heart as an endocrine organ with its own hormones and receptors, the biochemistry and physiology of the system have been translated into useful biomarkers and drug targets in cardiovascular disease ...
Theodor W, Shalmi +2 more
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Theodor W, Shalmi +2 more
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