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Atrial natriuretic peptide in man
American Journal of Nephrology, 1988The heart is the major source of atrial natriuretic peptides (ANP). A propeptide is stored in atrial myocytes. In normal humans, atrial distension secondary to volume overload and/or increased atrial pressures are thought to stimulate the secretion of biologically active alpha-ANP (ANF-[99-126], 28 amino residues) into the circulation.
Hermann Saxenhofer+3 more
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Natriuretic Peptide System and the Heart
2014The natriuretic peptide (NP) family includes atrial (ANP), brain or B-type (BNP) and C-type NP (CNP). A huge number of experimental and clinical studies, published in the 1st decade of this century, have added further support to the hypothesis that endocrine function in the human heart is a relevant component of a complex network including endocrine ...
Del Ry Silvia+2 more
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Over the last four decades, cardiac natriuretic peptides have changed our understanding of patients with chronic heart failure. From the discovery of the heart as an endocrine organ with its own hormones and receptors, the biochemistry and physiology of the system have been translated into useful biomarkers and drug targets in cardiovascular disease ...
Theodor W, Shalmi+2 more
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Theodor W, Shalmi+2 more
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[The cardiac natriuretic peptides].
Minerva medica, 2006Cardiac natriuretic peptides (including ANP, BNP, CNP and urodilatin) constitute a family of peptide hormones and neurotransmitters, sharing similar chemical structure (characterized by a cysteine bridge) and biological function. ANP and BNP are cardiac hormones because they are principally produced and secreted by cardiomyocytes.
S. Vittorini, M. Masini, CLERICO, ALDO
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Natriuretic peptide-guided management in heart failure
Journal of Cardiovascular Medicine, 2016O. Chioncel+7 more
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