Results 51 to 60 of about 25,222 (258)

Development of a population pharmacokinetic model using combined paediatric and adult data for four pulmonary arterial hypertension drugs

British Journal of Clinical Pharmacology, EarlyView.
Aims Pulmonary arterial hypertension (PAH) is a syndrome characterized by elevated pulmonary artery pressure. We developed a population pharmacokinetic (PPK) model using combined plasma drug concentration data from Japanese paediatric (<15 years) and adult (≥15 years) patients with PAH to investigate the pharmacokinetic characteristics of PAH ...
Motoyasu Miura, Shimako Tanaka, Ririka Aihara, Shun Yamamoto, Yasumi Nakashima, Yasuharu Kashiwagura, Akio Hakamata, Sachiko Miyakawa, Mariko Tatsuguchi, Keiichi Odagiri, Noriyuki Namiki, Naoki Inui, Hiroshi Watanabe, Shinya Uchida   +13 more
wiley   +1 more source

Natriuretic hormones in brain function

Frontiers in Endocrinology, 2014
Natriuretic hormones include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids.
David eLichtstein, Anastasia eHodes
doaj   +1 more source

Natriuretic Peptides in Heart Failure [PDF]

Clinical Chemistry, 2014
Heart failure is a major global health problem affecting 23 million people worldwide. As more cardiac patients survive and live longer with this progressive disease, heart failure is a condition for which the prevalence will grow. Based solely on clinical presentation, heart failure can be difficult to diagnose since its presentation is complex, with ...
D.C. Lin, E.P. Diamandis, JL J.r. Januzzi, A. Maisel, A.S. Jaffe, CLERICO, ALDO   +5 more
openaire   +3 more sources

The Impact of a Visualized Steerable Sheath on Radiofrequency Catheter Ablation for First‐Time Atrial Fibrillation Ablation: A Prospective, Randomized, Single‐Blind Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background A 3D electroanatomical mapping (3D‐EAM) visualized steerable sheath was designed to improve catheter placement and reduce radiation exposure during ablation, an established treatment for atrial fibrillation (AF). However, prospective randomized data comparing the procedural and clinical outcomes of visualized and non‐visualized ...
Chun‐Kai Chen, Chih‐Chieh Yu, Min‐Tsun Liao, Hui‐Chun Huang, Yen‐Bin Liu   +4 more
wiley   +1 more source

Cardiovascular natriuretic peptides in emergency

Emergency Care Journal, 2005
Natriuretic peptides have emerged as important candidates for development of diagnostic tools in cardiovascular disease being the establishment of the cause of shortness of breath in the acute setting (Emergency Department) one of most interesting ...
Martina Zaninotto, Monica Mion, Stefano Rocco, Mario Plebani   +3 more
doaj   +1 more source

Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition

Scientific Reports, 2021
Natriuretic peptides exert multiple effects by binding to natriuretic peptide receptors (NPRs). Osteocrin (OSTN) binds with high affinity to NPR-C, a clearance receptor for natriuretic peptides, and inhibits degradation of natriuretic peptides and ...
Takaya Handa, Keita P. Mori, Akira Ishii, Shoko Ohno, Yugo Kanai, Haruko Watanabe-Takano, Akihiro Yasoda, Takashige Kuwabara, Nobuyuki Takahashi, Naoki Mochizuki, Masashi Mukoyama, Motoko Yanagita, Hideki Yokoi   +12 more
doaj   +1 more source

Lower AKI Risk and Higher Survival With Microaxial Flow Pump Support During Elective PCI: A Propensity Score‐Matched Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Acute kidney injury (AKI) is associated with worse outcomes after percutaneous coronary intervention (PCI). Previous, smaller studies suggested nephroprotective effects of micro‐axial flow pump (mAFP) during PCI. This study aimed to compare renal outcomes of high‐risk PCI with mAFP or intraaortic balloon pump (IABP) support.
Elric Zweck, Andrew Shaw, Amin Polzin, Nudrat Noor, Sathya Unudurthi, Michael Cuchiara, Kai M. Schmidt‐Ott, Malte Kelm, Ralf Westenfeld, Rafael Kramann, Ravindra L. Mehta   +10 more
wiley   +1 more source

The High‐Sensitivity C‐Reactive Protein−Albumin−Lymphocyte Index Is a Prognostic Marker for All‐Cause and Cardiovascular Mortality in Patients With ST‐Elevation Myocardial Infarction

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Inflammation and immune dysfunction may worsen the prognosis of patients with ST‐segment elevation myocardial infarction (STEMI). Aims This study aimed to assess whether the high‐sensitivity C‐reactive protein–albumin–lymphocyte index (hsCALLYI) could be used to predict the prognosis of STEMI patients who received emergency ...
Xinuo Ma, Wei Zhang, Ningli Zhang, Qinghua Zhong, Tao Shi, Sirui Yang, Fazhi Yang, Yujuan Peng, Lixing Chen   +8 more
wiley   +1 more source

Natriuretic peptides as emerging biomarkers for coronary artery disease risk assessment

Asian Journal of Medical Sciences
The identification of novel biomarkers for coronary artery disease (CAD) risk stratification remains a critical priority in cardiovascular medicine. While natriuretic peptides – specifically atrial natriuretic peptide (ANP) and B-type natriuretic peptide
Ruby Dhar , Arun Kumar , Subhradip Karmakar   +2 more
doaj   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source