Results 41 to 50 of about 66,568 (219)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Rate of treatment demand of Omsk region population due to injuries caused by animals: dynamics and structure

Медицинский вестник Юга России
Objective: to analyze the rate of treatment demand after contact with animals in the Omsk region.Materials and methods: we used data of rate of treatment demand of Omsk region population due to injuries caused by animals in 2009–2022.
E. S. Savkina, E. M. Poleshchuk, G. N. Sidorov   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epidemiological Situation on Rickettsial Diseases and Q Fever in the Russian Federation over the Period of 2010–2023, Forecast for 2024

Проблемы особо опасных инфекций
The aim of the review is to forecast the incidence of rickettsial infections and Q fever in the Russian Federation for 2024 based on an analysis of the epidemiological situation in 2010–2023.
S. V. Shtrek, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, N. A. Pen’evskaya, L. V. Kumpan, A. V. Sannikov   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Retrospective Evaluation of Implementation of Long-Term Forecast on Spatial Spread of Rabies in the Asian Part of Russia

Проблемы особо опасных инфекций, 2020
Objective: To evaluate the historical long-term forecast of the spatial spread of rabies in Siberia and Far East and to characterize modern approaches to spatial forecasting.
A. D. Botvinkin, G. N. Sidorov, E. M. Poleshchuk, L. D. Zarva, D. N. Nashatyreva, N. V. Yakovchits, E. I. Andaev, S. V. Balakhonov, N. V. Rudakov   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Ixodidae Tick-Borne Borrelioses in the World. Epidemiological Situation in the Russian Federation in 2025 in Comparison with Long-Term Data and Forecast for 2026

Проблемы особо опасных инфекций
An overview of the epidemiological situation on Ixodidae tick-borne borreliosis (ITBB) in the world and the Russian Federation in 2025 in comparison with long-term values is presented. A forecast for 2026 is made.
N. A. Pen’evskaya, O. E. Teslova, Yu. F. Kuz’menko, A. I. Blokh, N. V. Rudakov, D. V. Trankvilevsky, S. V. Shtrek, D. A. Savel’ev   +7 more
doaj   +1 more source

Geographic information systems as a part of epidemiological surveillance for COVID-19 in urban areas

Фундаментальная и клиническая медицина, 2021
Aim. To identify clustering areas of COVID-19 cases during the first 3 months of pandemic in a million city.Materials and Methods. We collected the data on polymerase chain reaction verified cases of novel coronavirus infection (COVID-19) in Omsk for the
A. I. Blokh, N. A. Penyevskaya, N. V. Rudakov, O. A. Mikhaylova, A. S. Fedorov, A. V. Sannikov, S. V. Nikitin   +6 more
doaj   +1 more source