Results 51 to 60 of about 403 (213)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Retrospective Evaluation of Implementation of Long-Term Forecast on Spatial Spread of Rabies in the Asian Part of Russia

Проблемы особо опасных инфекций, 2020
Objective: To evaluate the historical long-term forecast of the spatial spread of rabies in Siberia and Far East and to characterize modern approaches to spatial forecasting.
A. D. Botvinkin, G. N. Sidorov, E. M. Poleshchuk, L. D. Zarva, D. N. Nashatyreva, N. V. Yakovchits, E. I. Andaev, S. V. Balakhonov, N. V. Rudakov   +8 more
doaj   +1 more source

Ways of Improving Epidemiological Surveillance of Natural Focal Infections

Epidemiology and Vaccine Prevention, 2016
The fundamental theoretical and methodological shortcomings of modern organisation and implementation of epidemiological surveillance of natural focal infections are considered. The conclusion is made about the need to prepare a realistic programme of observations of state change in natural focal parasitic systems and contacts of the population with ...
openaire   +3 more sources

SPONTANEOUS INFECTION OF HUNGRY IXODID TICKS (IXODIDAE) WITH NATURAL-FOCAL INFECTION AGENTS IN THE TOMSK REGION

CONCEPTUAL AND APPLIED ASPECTS OF INVERTEBRATE SCIENTIFIC RESEARCH AND BIOLOGICAL EDUCATION, 2020
The article presents data on infection of hungry ticks caught in natural biotopes of Tomsk region in spring-summer seasons 2017-2019. In ticks of Ixodes and Dermacentor genera the presence of pathogens of natural-focal diseases is established: CE virus, borrelia, ehrlichias, anaplasm, tularemia.
N.V. Poltoratskaya, T.N. Poltoratskaya, T.M. Pankina, A.V. Shikhin, M.V. Kondratyev, M.V. Goncharova, L.V. Polozova   +6 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ixodidae Tick-Borne Borrelioses in the World. Epidemiological Situation in the Russian Federation in 2025 in Comparison with Long-Term Data and Forecast for 2026

Проблемы особо опасных инфекций
An overview of the epidemiological situation on Ixodidae tick-borne borreliosis (ITBB) in the world and the Russian Federation in 2025 in comparison with long-term values is presented. A forecast for 2026 is made.
N. A. Pen’evskaya, O. E. Teslova, Yu. F. Kuz’menko, A. I. Blokh, N. V. Rudakov, D. V. Trankvilevsky, S. V. Shtrek, D. A. Savel’ev   +7 more
doaj   +1 more source

Geographic information systems as a part of epidemiological surveillance for COVID-19 in urban areas

Фундаментальная и клиническая медицина, 2021
Aim. To identify clustering areas of COVID-19 cases during the first 3 months of pandemic in a million city.Materials and Methods. We collected the data on polymerase chain reaction verified cases of novel coronavirus infection (COVID-19) in Omsk for the
A. I. Blokh, N. A. Penyevskaya, N. V. Rudakov, O. A. Mikhaylova, A. S. Fedorov, A. V. Sannikov, S. V. Nikitin   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chorological Structure of natural focal infections in the Asian part of the Russian Federation

Epidemiology and Vaccine Prevention, 2017
Division of the Asian part of the Russian Federation into southern and northern zones was implemented on the basis of physical-climatic features. The retrospective analysis of the natural focal infectious diseases in humans was carried out. Spectrum of nosological forms and epidemic process intensity in each of the evolved zones were established ...
A. K. Noskov, M. B. Sharakshanov, A. Ya. Nikitin   +2 more
openaire   +3 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source