Results 71 to 80 of about 97,627 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Development of quantitative criteria for assessing epidemic potential of the natural-focal viral infections

Russian Journal of Infection and Immunity, 2022
Notonly directly detected new infection, but also determining prerequisites for associated epidemiological complications becomes relevant with growing importance of new and recurring infections. As a result, a need to assess a degree of their epidemiological threat, or epidemic potential, i.e.
Marina V. Safonova, Elena G. Simonova, Anton A. Lopatin, Anna S. Dolgova, Vladimir G. Dedkov   +4 more
openaire   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Dynamics and structure of mortality of patients with HIV infection in the Siberian federal district in 2006–2015

Журнал инфектологии, 2017
Objective: studying of dynamics, level, structure, features of territorial distribution of a mortality of patients with HIVinfection in the Siberian Federal District in 2015.Materials and methods: observation descriptive and estimated epidemiological ...
O. A. Pasechnik, L. I. Levahina, A. T. Tyumentsev, N. D. Pitsenko   +3 more
doaj   +1 more source

Epidemic Potential of COVID-19 in Omsk Region during Anti-Epidemic Measures

Проблемы особо опасных инфекций, 2020
Aim. To study the spread of COVID-19 among the population of the Omsk Region during 24 weeks of the epidemic on the background of anti-epidemic measures.Materials and methods.
A. I. Blokh, N. A. Pen’evskaya, N. V. Rudakov, I. I. Lazarev, O. A. Mikhailova, A. S. Fedorov, Y. A. Pnevsky   +6 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Analysis of the Causes and Conditions for the Formation of a High Incidence of Acute Respiratory Infections in the Population of the Altai Krai (Part 2. Environmental factors, diagnosis of coxiellosis and tick­borne rickettsiosis)

Эпидемиология и вакцинопрофилактика
Relevance. Altai Krai (AK) is one of the least prosperous subjects of the Russian Federation in terms of the incidence of acute respiratory infections (ARI).
A. I. Blokh, N. A. Pen'evskaya, N. V. Rudakov, S. V. Shtrek, S. N. Shpynov, O. F. Egorova, Kh. A. Manokhina, D. A. Saveliev, S. Yu. Krasotkina   +8 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Epidemiological Situation on Rickettsioses in the Russian Federation in 2013–2024 and Short-Term Incidence Forecast for 2025

Проблемы особо опасных инфекций
The aim of the review was to conduct a comparative analysis of the epidemiological situation regarding rickettsioses in the constituent entities of the Russian Federation for the period of 2013–2024, and to provide a forecast of the incidence for 2025 ...
S. V. Shtrek, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, D. A. Savel’ev, N. A. Pen’evskaya, A. V. Sannikov, I. E. Irishkova, O. N. Skudareva   +9 more
doaj   +1 more source

Epizootiological Monitoring of Natural Focal Infections in the South of the European Part of the Russian Federation in 2017

, 2019
Objective – analysis of epizootiological manifestations of natural focal infections in the territory of the south of the European part of the Russian Federation in 2017.Materials and methods.
L. I. Shaposhnikova, O. V. Maletskaya, Ya. V. Lisitskaya, E. A. Manin, T. V. Taran, A. N. Kulichenko, N. F. Vasilenko, N. G. Varfolomeeva, D. A. Prislegina, A. S. Volynkina, O. V. Semenko, E. V. Gerasimenko   +11 more
core   +1 more source