Results 81 to 90 of about 97,627 (295)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Epidemiological situation of natural focal infections in the Volgograd region in 2022

Journal of Volgograd State Medical University
The article is devoted to the analysis of the epidemiological situation of natural focal infections (NFI) in the Volgograd region in 2022. Materials and methods: The work used the official statistics of the institutions of Rospotrebnadzor on NFI for 2022. The main research method is epidemiological analysis.
Vladimir P. Smelyansky, Kirill V. Zhukov, Dmitry N. Nikitin, Stanislav A. Kargashin, Irina A. Klimina, Maria N. Taratutina, Elena I. Romasova, Evgeniya V. Kondratenko   +7 more
openaire   +1 more source

SPONTANEOUS INFECTION OF HUNGRY IXODID TICKS (IXODIDAE) WITH NATURAL-FOCAL INFECTION AGENTS IN THE TOMSK REGION

CONCEPTUAL AND APPLIED ASPECTS OF INVERTEBRATE SCIENTIFIC RESEARCH AND BIOLOGICAL EDUCATION, 2020
The article presents data on infection of hungry ticks caught in natural biotopes of Tomsk region in spring-summer seasons 2017-2019. In ticks of Ixodes and Dermacentor genera the presence of pathogens of natural-focal diseases is established: CE virus, borrelia, ehrlichias, anaplasm, tularemia.
N.V. Poltoratskaya, T.N. Poltoratskaya, T.M. Pankina, A.V. Shikhin, M.V. Kondratyev, M.V. Goncharova, L.V. Polozova   +6 more
openaire   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Epidemiological Situation on Natural Focal Viral Infections in the Territory of the Stavropol Region

Problems of Particularly Dangerous Infections, 2011
Landscape-geographical and climatic peculiarities of the Stavropol Region, high abundance of mosquito and ticks, the diversity of wild mammal and bird species, developed agriculture and infrastructure create favorable conditions for circulation of arboviruses and hantaviruses, emergence of cases of viral infections, which sometimes cause serious ...
N. G. Varfolomeeva, A. V. Ermakov, N. F. Vasilenko, G. P. Shkarlet, O. V. Maletskaya, O. A. Kireitseva, I. N. Zaikina, A. N. Kulichenko   +7 more
openaire   +3 more sources

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Immunological (serological) monitoring in the epidemiological surveillance system of natural - focal infections

Epidemiology and Infectious Diseases, 2016
In this work there is shown the value of the immunological screening in the organization and implementation of the epidemiological surveillance of natural focal infections. The application of this method with regard to this group of infections, allows to detect the frequency and the level of so-called "pro-epidemising" of the population, also helps ...
A. A Nafeev, N. V Savelyeva, E. I Sibaeva   +2 more
openaire   +1 more source

Epidemiological Situation on Natural Focal Infectious Diseases in the Territory of the North-Caucasian Federal District in 2015

, 2016
Objective of the study is to analyze epidemiological and epizootiological manifestations of natural-focal infections in the territory of the North-Caucasian Federal District (NCFD) in 2015. Materials and methods.
V. M. Dubyansky, L. I. Shaposhnikova, O. V. Maletskaya, Ya. V. Lisitskaya, E. A. Manin, T. V. Taran, A. N. Kulichenko, N. F. Vasilenko, D. A. Prislegina, A. S. Volynkina, E. S. Kotenev, G. M. Grizhebovsky   +11 more
core   +1 more source

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections. [PDF]

, 2010
BACKGROUND: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox-Singh, J, Siti Khatijah, Binti Zakaria, Daneshvar, C., Zakaria Siti K, Paul CS Divis, Daneshvar, C, Singh Balbir, Balbir, Singh, Divis Paul CS, Rafa'ee, Mohammad Z., Singh, Balbir, Janet Cox-Singh, Daneshvar, Cyrus, Mohammad Zakri, Rafa’ee, Rafa'ee Mohammad Z, Divis, Paul C. S., Singh, B, Balbir Singh, Daneshvar Cyrus, Cox-Singh Janet, Timothy ME Davis, Siti K Zakaria, Zakaria, SK, Davis, T.M.E, Cyrus CyrusDaneshvar, Paul C, Divis, Cox Singh, Janet, Davis, TM, Davis, Timothy M. E., Rafa'ee, MZ, Davis Timothy ME, Mohammad Z Rafa'ee, Cox-Singh, J., Cyrus Daneshvar, Zakaria, Siti K., Divis, PC   +35 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source