Results 91 to 100 of about 21,073,882 (364)

A Theory of Natural Addiction [PDF]

, 2007
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie, Atkinson, Attila Tasnádi, Baldwin, Baron-Cohen, Becker, Becker, Bergstrom, Blass, Blass, Blass, Bodnar, Booth, Brick, Camerer, Camerer, Campbell, Carson-DeWitt, Chiara, Cohen, Colantuoni, Cooper, Cooper, Cummings, Deth, Drewnowski, Dudley, Dum, Fantino, Fehr, Foster, Gilbertson, Gillberg, Gosnell, Griffiths, Grossman, Gruber, Gul, Harrigan, Headlee, Hirshleifer, Hirshleifer, Holtzman, Jaffe, Kahneman, Kalat, Kavaliers, Kavaliers, Killian, Laibson, Laibson, Leboyer, Leboyer, Loewenstein, Martin, McKim, Mello, Mercer, Morley, Mucha, Mucha, Nelson, Nesse, Nesse, Orphanides, Orphanides, Ostrowski, Parfitt, Pert, Pomerleau, Raiten, Raven, Robson, Rogers, Rudski, Samuelson, Sanger, Savage, Schuckit, Si, Simon, Simpkins, Smith, Sozou, Spanagel, Sullivan, Sullivan, ter Riet, Terenius, Trenton G. Smith, van Ree, van Ree, van Ree, Waeltl, Weeks, Weeks, Weiss, Williams, Yamamoto, Yeomans, Yeomans, Yeomans, Zigmond   +102 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Experimental Investigation of Opuntia ficus-indica Mucilage as a Concrete Admixture for Sustainable Construction

Ethiopian Journal of Science and Sustainable Development
The key properties of concrete are often controlled using synthetic admixtures, despite their possible adverse environmental effects. This study tested the potential of Opuntia ficus-indica (OFI) liquid mucilage as a natural and sustainable concrete ...
Besrat Berhanu, Zenagebriel Gebremedhn Khshen   +1 more
doaj   +1 more source

Comprehensive analysis of peripheral T-cell and natural killer/T-cell lymphoma in Asian patients: A multinational, multicenter, prospective registry study in Asia [PDF]

, 2021
Sang Eun Yoon, Yuqin Song, Seok Jin Kim, Dok Hyun Yoon, Tsai‐Yun Chen, Youngil Koh, Ka‐Won Kang, Ho Sup Lee, Kevin Tay, Soon Thye Lim, M. Poon, Cosphiadi Irawan, Weili Zhao, Young Rok, Mark Hong Lee, Soo Chin Ng, Won Sik Lee, Ye Guo, Huilai Zhang, Hye Jin Kang, Hwan‐Jung Yun, Hyo Jung Kim, Daryl Tan Chen Lung, Jae-Yong Kwak, Jae Joon Han, Yeung‐Chul Mun, Sung Yong Oh, Hyeok Shim, Jung Hye Kwon, Byeong Seok Sohn, Seong Kyu Park, Jae-Cheol Jo, Young Hyeh Ko, Zhu Jun, Won Seog Kim   +34 more
openalex   +1 more source

A global model of natural volatile organic compound emissions

, 1995
Numerical assessments of global air quality and potential changes in atmospheric chemical constituents require estimates of the surface fluxes of a variety of trace gas species.
A. Guenther, C. Hewitt, D. Erickson, R. Fall, C. Geron, Tom, Graedel, P. Harley, L. Klinger, M. Lerdau, W. A. Mckay, T. Pierce, B. Scholes, R. Steinbrecher, R. Tallamraju, John A. Taylor, Pat, Zimmerman   +17 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Natural Hazard Overview: Landslides [PDF]

, 2018
The National Centre for Resilience supported the Met Office and their partner organisations in the production of a set of Natural Hazard Overviews. This factsheet is one of the set commissioned to meet a requirement for Scotland-specific information ...
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core  

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The DBSCAN Clustering Algorithm on P Systems [PDF]

, 2019
We show how to implement the DBSCAN clustering algorithm (Density Based Spatial Clustering of Applications with Noise) on membrane systems using evolution rules with promoters and ...
Research Group on Natural Computing (Coordinador), Vaszil, György   +1 more
core