Results 61 to 70 of about 1,183,079 (307)

Increasing occurrence of cold and warm extremes during the recent global warming slowdown. [PDF]

, 2018
The recent levelling of global mean temperatures after the late 1990s, the so-called global warming hiatus or slowdown, ignited a surge of scientific interest into natural global mean surface temperature variability, observed temperature biases, and ...
Johnson, Nathaniel C, Kosaka, Yu, Li, Xichen, Xie, Shang-Ping   +3 more
core   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Coupled Ocean Atmosphere Processes and European Climate (COAPEC): improved understanding of the coupled climate system [PDF]

, 2004
COAPEC (http://coapec.nerc.ac.uk/) is a five-year Directed Science Programme funded by the Natural Environment Research Council (NERC). COAPEC is providing advances in understanding the mechanisms by which the ocean and atmosphere interact, how these ...
Black, E., Iwi, A., Sinha, B., Snaith, H.M.   +3 more
core  

Leray and LANS-$\alpha$ modeling of turbulent mixing [PDF]

, 2005
Mathematical regularisation of the nonlinear terms in the Navier-Stokes equations provides a systematic approach to deriving subgrid closures for numerical simulations of turbulent flow.
Bardina J., Bernard J. Geurts, Berselli L. C., Bos F. van der, Cao C., Cheskidov A., Darryl D. Holm, Domaradzki J. A., Foias C., Frisch U., Germano M., Germano M., Germano M., Geurts B. J., Geurts B. J., Geurts B. J., Geurts B. J., Geurts B. J., Geurts B. J., Ghosal S., Holm D. D., Holm D. D., Holm D. D., Holm D. D., Horiuti K., Jameson A., Kolmogorov A. N., Kuerten J. G.M., Leray J., Lilly D. K., Meneveau C., Meneveau C., Meyers J., Meyers J., Moser R. D., Sagaut P., Smagorinsky J., Speziale C. G., Stolz S., Vreman A. W., Vreman A. W., Vreman A. W., Vreman A. W., Vreman A. W., Winckelmans G. S.   +44 more
core   +3 more sources

Desired Circulation Ratio for Natural Circulation in Water-Tube Boiler

International Journal of Recent Technology and Engineering (IJRTE), 2020
The basic objective of the paper is to identify the desired circulation ratio for the natural circulation of water tube boilers in different operating conditions. This requires the basic study of heat flux and the mode of the boiling heat transfer, and the phenomenon like a departure from nucleate boiling and tube overheating.
Atul M. Elgandelwar*, R.S. Jha, Mandar M. Lele   +2 more
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Development and analysis of passive residual heat-removal system on secondary side of small reactor

He jishu
BackgroundPassive residual heat-removal system (PRHRS) based on natural circulation has been widely used in small reactors connected on secondary side loop.PurposeThis study aims to develop and analyze a passive residual heat-removal system on the ...
DONG Botong, XIAO Yao, LI Junlong, XU Ziyi, LIU Maolong, LIU Limin, FU Junsen, GU Hanyang   +7 more
doaj   +1 more source

Aerosol and Cloud Microphysical Characteristics of Rifts and Gradients in Maritime Stratocumulus Clouds [PDF]

, 2006
A cloud rift is characterized as a large-scale, persistent area of broken, low-reflectivity stratocumulus clouds usually surrounded by a solid deck of stratocumulus.
Albrecht, Bruce A., Flagan, Rick, Jonsson, Haflidi H., Khaiyer, Mandana M., Minnis, Patrick, Seinfeld, John, Sharon, Tarah M., van Reken, Timothy M.   +7 more
core   +2 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source