Results 41 to 50 of about 1,183,079 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Research on Behavior of Natural Circulation of Coolant in Primary Circuit System of Pool Type Fast Reactor

open access: yesYuanzineng kexue jishu
Thermal-hydraulic phenomenon of coolant in the primary circuit of pool type fast reactor under accident decay heat removal conditions is complicated because the layout of direct heat exchanger.
CHENG Daoxi, ZHANG Xuefeng, DU Kaiwen, ZHAI Weiming, QI Xiaoguang, ZHOU Ping, YU Song, MA Xiaoyao, LI Ruizhi
doaj   +1 more source

Natural circulation FLiBe loop overview

open access: yesInternational Journal of Heat and Mass Transfer, 2019
Abstract A new large natural circulation FLiBe loop has operated for the first time in 40 years. Reaching temperatures above 700 °C with stable flow rates around 5 cm/s, the loop exhibits a range of flow phenomena pertinent to high temperature natural circulation safety systems for nuclear reactors.
Karl Britsch   +3 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Study on Inherent Safety Characteristic on Thermal-hydraulic of Pool-type Sodium-cooled Fast Reactors

open access: yesYuanzineng kexue jishu, 2023
The concept of the inherent safety characteristic on thermal-hydraulic of the pool-type sodium-cooled fast reactor was proposed and its formation mechanism was analyzed.
ZHOU Zhiwei;XUE Xiuli;YANG Yong;YANG Hongyi
doaj  

Heat transfer characteristics of one side heated vertical rectangular channel applied as vessel cooling system of VHTR

open access: yesNihon Kikai Gakkai ronbunshu, 2018
A Very High Temperature Reactor (VHTR) is a next generation nuclear reactor system. From a view point of safety characteristic, a passive cooling system should be designed for the VHTR as a best way of a reactor vessel cooling system (VCS).
Kenta FUJIKAMI, Tetsuaki TAKEDA
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Research on Flow and Heat Transfer Characteristics in Helical-coiled Tube under Motion Condition

open access: yesYuanzineng kexue jishu, 2022
Natural circulation technology and helical-coiled tube steam generator are widely adopted in marine nuclear power system design due to the inherent safety feature of natural circulation and high heat transfer coefficient of helicalcoiled steam ...
ZHU Zhiming;LI Kepiao;ZHANG Kui;TIAN Wenxi;CHEN Ronghua;QIU Suizheng
doaj  

Hello! Or, How I Got Here [PDF]

open access: yes, 2012
If you frequent the library, chances are you’ve seen me at the circulation desk. I’ve been a circulation desk assistant since my freshman orientation almost two years ago.
Leone, Hannah R.
core   +1 more source

Natural Circulation in Nuclear Reactor Systems [PDF]

open access: yesScience and Technology of Nuclear Installations, 2008
C'est avec grand plaisir que nous publions ce numéro spécial sur « La circulation naturelle dans les systèmes de réacteurs nucléaires » qui revêt une importance particulière dans le contexte des scénarios actuels de la technologie énergétique. Aujourd'hui, l'énergie nucléaire produit environ 15 % de l'électricité mondiale totale.
Dilip Saha, J.C. Cleveland
openaire   +2 more sources

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