Results 41 to 50 of about 309,633 (267)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Research Progress in Key Thermal-hydraulic Issue of Sodium-cooled Fast Reactor

Yuanzineng kexue jishu
Sodium-cooled fast reactors are considered the preferred reactor type for fourth generation nuclear energy systems due to their high thermal efficiency, high fuel utilization efficiency, inherent safety, and unique advantages of achieving a closed fuel ...
YANG Hongyi1, XUE Xiuli1, , , ZHOU Zhiwei1, LIN Chao1, LI Hongrui2, GAO Xinzhao1, YU Xintai1, MA Xiao1, XIAO Yubai1, LUO Rui2
doaj   +1 more source

Circulating natural killer cells in sjögren's syndrome [PDF]

Arthritis & Rheumatism, 1985
AbstractReduced natural killer (NK) cell activity of peripheral blood lymphocytes (PBL) has been reported in a number of diseases including Sjögren's syndrome (SS). In this study, we used 2 monoclonal antibodies directed toward NK cells (anti‐Leu‐7 and anti‐Leu‐11) for determining NK cell activity in 29 patients with SS (9 with primary SS and 20 with ...
Y, Ichikawa, M, Yoshida, M, Takaya, M, Uchiyama, H, Shimizu, S, Arimori   +5 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Assessment of stability of natural circulation in the first circuit of small modular reactors.

Trudy Odesskogo Politehničeskogo Universiteta
The work contains the results of the study of the influence of the architecture and operating parameters of the water-based modular reactor plant on its functioning in the mode of natural circulation of the coolant of the first circuit.
Вячеслав Іванович Ковальчук, Ігор Леонідович Козлов, Олег Олексадрович Чулкін, Костянтин Дмитрович Карчев, Вячеслав Петрович Мілєв   +4 more
doaj   +3 more sources

Study on Natural Circulation Heat Transfer Characteristics of Different Liquid Metals Based on Factor Analysis

Frontiers in Energy Research, 2020
The study of the commonness and differences of natural circulation of different liquid metals plays an important role in improving the safety of reactors.
Feng Xiang, Feng Xiang, Feng Xiang, Zhou Tao, Zhou Tao, Zhou Tao, Zhang Jialei, Zhang Jialei, Zhang Jialei, Zhang Boya, Zhang Boya, Zhang Boya, Chen Juan, Chen Juan, Chen Juan   +14 more
doaj   +1 more source

Research on core power maximization method of natural circulation lead-bismuth cooled fast reactor

Frontiers in Energy Research, 2022
To improve the inherent safety and cost-effectiveness of lead-bismuth cooled fast reactors, the SPALLER-100 reactor designed by the University of South China has been selected as the research object to determine the maximum power it can produce.
Yingjie Xiao, Junkang Yang, Pengcheng Zhao, Pengcheng Zhao, Tao Yu, Zijing Liu   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

CFD Investigation of MHTGR Natural Circulation and Decay Heat Removal in P-LOFC Accident

Frontiers in Energy Research, 2020
One of the key postulated accidents in a high-temperature gas-cooled reactor (HTGR) is the pressurized loss of forced cooling (P-LOFC) of the primary loop, which can be triggered by its primary helium circulator trip or turbine trip.
Chengqi Wang, Xiaodong Sun, Piyush Sabharwall   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source