Results 41 to 50 of about 623,231 (263)

Quantitative assessment of the impacts of climate and human activities on streamflow of the Lancang-Mekong river over the recent decades

Frontiers in Earth Science, 2023
The impacts of climate and human activities exerted on streamflow over the recent decades in the Lancang-Mekong River Basin (LMRB) have been examined in separate forms and this study performed an integrated quantitative evaluation.
Renzhi Li, Renzhi Li, He Qing Huang, He Qing Huang, Zhonggen Wang, Zhonggen Wang, Ruxin Zhao   +6 more
doaj   +1 more source

Natural Compounds with Antimicrobial Properties in Cosmetics

Pathogens, 2023
Currently, the cosmetic industry is a very intensively growing part of the economy. Consumer demands are adapted to the current lifestyle, which is based on technological innovations and awareness of the impact of various factors on human health and fitness.
Kamila Rybczyńska-Tkaczyk, Anna Grenda, Anna Jakubczyk, Kaja Kiersnowska, Marta Bik-Małodzińska   +4 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Disaster analysis and lessons learned from the July 22, 2024, Ethiopian landslide

Earthquake Research Advances
Rainfall-induced landslides are often highly destructive. Reviewing and analyzing the causes, processes, impacts, and deficiencies in emergency response is critical for improving disaster prevention and management.
Tao Li, Junxue Ma, Yuandong Huang, Shuhui Zhang, Huiran Gao, Chong Xu   +5 more
doaj   +1 more source

Cancer Prevention by Natural Compounds

Drug Metabolism and Pharmacokinetics, 2004
Increasing attention is being paid to the possibility of applying cancer chemopreventive agents for individuals at high risk of neoplastic development. For this purpose by natural compounds have practical advantages with regard to availability, suitability for oral application, regulatory approval and mechanisms of action.
TSUDA, Hiroyuki, OHSHIMA, Yutaka, NOMOTO, Hiroshi, FUJITA, Ken-ichi, MATSUDA, Eiji, IIGO, Masaaki, TAKASUKA, Nobuo, MOORE, Malcolm A.   +7 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Beyond structured knowledge: performance boundaries of ChatGPT in geological-hazard question answering and the need for human-in-the-loop oversight

Frontiers in Earth Science
Large language models have shown promise across specialized domains, but their performance limits in disaster risk reduction remain poorly understood. We conduct a version-specific evaluation of ChatGPT-4o for geological-hazard question answering using a
Saier Wu, Saier Wu, Chong Xu, Chong Xu, Zhiwen Xue, Zhiwen Xue, Zhiwen Xue, Yuandong Huang, Yuandong Huang, Yuandong Huang, Guoguo Xu, Guoguo Xu, Guoguo Xu, Yulong Cui, Junxue Ma, Junxue Ma, Ruixia Ma, Ruixia Ma, Ruixia Ma, Chenchen Xie, Chenchen Xie, Chenchen Xie   +21 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source