Results 41 to 50 of about 647,940 (263)

Automated machine learning for rainfall-induced landslide hazard mapping in Luhe County of Guangdong Province, China

China Geology
: Landslide hazard mapping is essential for regional landslide hazard management. The main objective of this study is to construct a rainfall-induced landslide hazard map of Luhe County, China based on an automated machine learning framework (AutoGluon).
Tao Li, Chen-chen Xie, Chong Xu, Wen-wen Qi, Yuan-dong Huang, Lei Li   +5 more
doaj   +1 more source

Natural Compounds with Antimicrobial Properties in Cosmetics

Pathogens, 2023
Currently, the cosmetic industry is a very intensively growing part of the economy. Consumer demands are adapted to the current lifestyle, which is based on technological innovations and awareness of the impact of various factors on human health and fitness.
Kamila Rybczyńska-Tkaczyk, Anna Grenda, Anna Jakubczyk, Kaja Kiersnowska, Marta Bik-Małodzińska   +4 more
openaire   +3 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Quantitative assessment of the impacts of climate and human activities on streamflow of the Lancang-Mekong river over the recent decades

Frontiers in Earth Science, 2023
The impacts of climate and human activities exerted on streamflow over the recent decades in the Lancang-Mekong River Basin (LMRB) have been examined in separate forms and this study performed an integrated quantitative evaluation.
Renzhi Li, Renzhi Li, He Qing Huang, He Qing Huang, Zhonggen Wang, Zhonggen Wang, Ruxin Zhao   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Disaster analysis and lessons learned from the July 22, 2024, Ethiopian landslide

Earthquake Research Advances
Rainfall-induced landslides are often highly destructive. Reviewing and analyzing the causes, processes, impacts, and deficiencies in emergency response is critical for improving disaster prevention and management.
Tao Li, Junxue Ma, Yuandong Huang, Shuhui Zhang, Huiran Gao, Chong Xu   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Beyond structured knowledge: performance boundaries of ChatGPT in geological-hazard question answering and the need for human-in-the-loop oversight

Frontiers in Earth Science
Large language models have shown promise across specialized domains, but their performance limits in disaster risk reduction remain poorly understood. We conduct a version-specific evaluation of ChatGPT-4o for geological-hazard question answering using a
Saier Wu, Saier Wu, Chong Xu, Chong Xu, Zhiwen Xue, Zhiwen Xue, Zhiwen Xue, Yuandong Huang, Yuandong Huang, Yuandong Huang, Guoguo Xu, Guoguo Xu, Guoguo Xu, Yulong Cui, Junxue Ma, Junxue Ma, Ruixia Ma, Ruixia Ma, Ruixia Ma, Chenchen Xie, Chenchen Xie, Chenchen Xie   +21 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source