Results 81 to 90 of about 8,668,298 (309)

Lyso-DGTS Lipid Derivatives Enhance PON1 Activities and Prevent Oxidation of LDL: A Structure–Activity Relationship Study

Antioxidants, 2022
Paraoxonase 1 (PON1) plays a role in regulating reverse cholesterol transport and has antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities.
Ali Khattib, Sanaa Musa, Majdi Halabi, Tony Hayek, Soliman Khatib   +4 more
doaj   +1 more source

Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Pharmaceutics, 2021
Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage.
M. Matos, José D Anastácio, C. Santos
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Determination of the Elemental Composition of Aromatic Plants Cultivated Industrially in the Republic of Moldova Using Neutron Activation Analysis

Agronomy, 2021
The mineral contents of roots, leaves, stalks, and inflorescences of the aromatic plant species Anethum graveolens L., Coriandrum sativum L., Lavandula angustifolia Mill., Levisticum officinale W.D.J. Koch, and Salvia sclarea L.
Alexandru Ciocarlan, Gergana Hristozova, Aculina Aricu, Ion Dragalin, Inga Zinicovscaia, Nikita Yushin, Dmitrii Grozdov, Violeta Popescu   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen
Interest in piperazine scaffolds continues to rise due to their broad relevance across anti‐infective, anticancer, and neuroactive research. This review examines reports published from 2014 to 2024 and organizes current developments by therapeutic class,
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
doaj   +1 more source

Nanoemulsion-Based Delivery of Essential Oils for Controlling Foodborne Pathogens and Spoilage Microorganisms

Micro
The increasing incidence of foodborne diseases and the limitations of conventional preservation methods have driven the search for safer, more effective, and sustainable antimicrobial strategies.
Diego Pádua de Almeida, Paula Zambe Azevedo, Ramila Cristiane Rodrigues, Elisa de Paula Reis Lima, Paulo Cesar Stringueta, Pedro Henrique Campelo, Evandro Martins   +6 more
doaj   +1 more source

Application of delayed luminescence method on measuring of the processing of Chinese herbal materials

Chinese Medicine, 2018
Background Based on the principle of tradition Chinese medicine, the processing refers to various techniques that alter the overall properties of herbal materials to meet the requirements of therapeutic applications.
Mengmeng Sun, Wen-Te Chang, Eduard Van Wijk, Min He, Roeland Van Wijk, Mei Wang   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source