Results 31 to 40 of about 2,364 (141)

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Interfacial Polarization Dynamics of Nitrile Dipoles in Organic Synaptic Transistors for Acoustic Reservoir Computing

Advanced Science, EarlyView.
Interfacial nitrile dipoles unlock tunable memory in organic synaptic transistors through competing polarization and relaxation. Their finite time dynamics are directly harnessed for acoustic reservoir computing, delivering 97.17% spoken digit recognition, reliable speech emotion and snoring recognition, and an ultralow event energy of only 50 aJ ...
Yutian Liu, Jiale Huang, Haoran Fang, Jichen Zhao, Fan Ye, Bo Huang, Ruibin Liang, Jintao Xu, Fanqi Wang, Mingjun Huang, Zhiming Lin, Shuguang Zhang, Linfeng Lan, Junbiao Peng   +13 more
wiley   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

Advanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim, Seoa Kim, Erik A. Wu, Darren H. S. Tan, Shawn Peng, Xiaolin Li   +5 more
wiley   +1 more source

Locally Competitive Coordination Electrolyte for High‐Voltage Lithium‐Metal Batteries With Ni‐Rich Cathodes

Advanced Energy Materials, EarlyView.
A locally competitive coordination electrolyte, formulated with a nitrile‐based solvent, dual borate salts, and ether co‐solvents and diluents, concurrently stabilizes Ni‐rich positive and Li‐metal negative electrodes. This design suppresses parasitic reactions while forming an inorganic‐rich SEI, enabling Li‐metal cells to stably cycle under stringent
Jianqi Sun, Juliane Fiates, Kohei Shimokawa, Qingsong Weng, Heng Wang, Zhuangnan Li, Su Jin Heo, Hooman Abbasi, Minfei Fei, Tianhao Wu, Yaogang Li, Hongzhi Wang, James A Dawson, Michael De Volder   +13 more
wiley   +1 more source

A Convergent Materials Design Paradigm Across Electro‐ and Photocatalysis for Sustainable Hydrogen Peroxide Production

Carbon Energy, EarlyView.
This review outlines advanced modification strategies for electrocatalytic and photocatalytic H2O2 production, covering bandgap tuning, defect engineering, heterostructure construction, cocatalyst loading, and functional framework design. Structure‐performance correlations are revealed across catalysts such as metal oxides, sulfides, carbon nitrides ...
Na Li, Jie Zhou, Yazhou Zhou, Zhen Yang, Yufeng Wang, Bo Weng, Jinyang Chen, Mingchao Shao, Minfeng Zeng, Wei Zong   +9 more
wiley   +1 more source

Applications of Biomaterials in Separators for Secondary Batteries

Carbon Energy, EarlyView.
In this review, biomaterial‐based separators are reviewed as sustainable alternatives to conventional polyolefin‐based separators. For 12 different natural polymers, spanning from Protista, Plantae, and Animalia, viable strategies for synthesizing biomass‐based separators are described.
Jongyoung Choi, Sung Cik Mun, Yong‐Seok Choi, Jong Ho Won   +3 more
wiley   +1 more source

Carbon Anodes for Low‐Temperature Nonaqueous Alkali Metal‐Ion Batteries

EcoEnergy, EarlyView.
This review summarizes recent progress in carbon anodes for low‐temperature nonaqueous alkali‐metal ion batteries. Fundamental thermodynamic and kinetic limitations are examined, alongside a systematic discussion of graphite, hard carbon, and emerging carbon architectures.
Zhichun Miao, Dandan Yu, Guojie Liu, Yuyang Qin, Jingyun Mou, Wenlong Song, Lu Shi, Zengqin Xiao, Xin Yuan, Huayu Chen, Laishun Qin, Da Chen   +11 more
wiley   +1 more source