Results 61 to 70 of about 2,096 (139)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Dual‐Mode Conductive Hydrogel Sensor Combining Triboelectric and Piezoresistive Mechanisms for Signal Differentiation and Verification

Advanced Electronic Materials, Volume 12, Issue 12, 22 June 2026.
A hierarchical poly(vinyl alcohol)/polyaniline‐silver nanoparticle hydrogel is developed as a dual‐mode sensor to overcome single‐mechanism limitations. By synchronizing triboelectric and piezoresistive signals, this device differentiates between mechanical touch and environmental moisture, offering high sensitivity and real‐time signal decoupling ...
Nebiyou Tadesse Debele, Tinsae Messay Abebaw, Yong Tae Park   +2 more
wiley   +1 more source

Functional Fertilizers: Potash‐Tuned Prussian Blue Analogues for Potassium‐Ion Battery Cathodes

Advanced Energy and Sustainability Research, Volume 7, Issue 6, June 2026.
Prussian blue analogue nanoparticles exhibit enhanced electrochemical performance as cathode materials for potassium‐ion batteries when synthesized using commonly available commercial‐grade potash fertilizers. Chloride‐based potash slightly enhances the achieved specific capacity, whereas magnesium sulfate‐based langbeinite promotes the formation of an
Austin Choi, Juanjuan Lu, Haiyan Wang, Vilas G. Pol   +3 more
wiley   +1 more source

TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates TCM syndrome differentiation‐guided targeted strategies against NLRP3 inflammasome‐mediated non‐alcoholic fatty liver disease (NAFLD). Metabolic dysfunction and gut‐liver axis dysregulation drive NAFLD progression, activating the NLRP3 inflammasome (comprising NLRP3, ASC, caspase‐1) to trigger cytokine release (IL‐1β,
Yanxia Zhang
wiley   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

The effects of single versus successive warm summers on an intertidal community

Oikos, Volume 2026, Issue 6, June 2026.
To accurately predict how organisms and ecological communities will respond to future conditions caused by climate change, we must consider the temporal dynamics of environmental stressors, including the effects of repeated exposures to stress. We performed a two‐year passive thermal manipulation in coastal British Columbia, Canada to determine how ...
Amelia V. Hesketh, Cassandra A. Konecny, Sandra M. Emry, Christopher D. G. Harley   +3 more
wiley   +1 more source

Advances in BiOCl‐Based Photocatalysts: From Synthesis, Structural Tailoring to Solar Energy Conversion

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Semiconductor photocatalysis represents a pivotal frontier in the quest for sustainable energy and environmental remediation. Among the diverse catalytic materials, Bismuth Oxychloride (BiOCl) has emerged as a particularly promising candidate due to its unique layered structure, featuring [Bi2O2]2+ layers intertwined with halogen ions, which ...
Liu Han, Bin Wu, Jie Wang, Yang Su, Yingtang Zhou, Zhongyi Jiang   +5 more
wiley   +1 more source

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

Aging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing, Jingjing Su, Yanjun Lin, Nengwen Huang, Sihui Zhang, Yuwei Zhou, Jie Lu, Weiping Chen, Kaixun He, Wenxiu Yuan, Yang Li, Geyuan Zheng, Pengyuan Hu, Dong Wu, Yanjing Ou, Jiang Chen   +15 more
wiley   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4121-4135, June 2026.
ABSTRACT Cassava (Manihot esculenta Crantz) exhibits exceptional tolerance to infertile soils and contains abundant cyanogenic glucosides (CGs). Previous research has indicated that CGs can serve as a significant reservoir of organic nitrogen in plants.
Weitao Mai, Ruxue Bao, Xiaocheng Liu, Mengtao Li, Jinling Zhao, Huaifang Zhang, Yuan Yao, Haiyan Wang, Wenquan Wang, Changying Zeng, Xin Chen   +10 more
wiley   +1 more source