Results 21 to 30 of about 82,761 (262)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Resistência Natural de Quatro Espécies Florestais Submetidas a Ensaio com Fungos Apodrecedores

Floresta e Ambiente
Este estudo teve como objetivo avaliar a durabilidade natural das madeiras de Eucalyptus dunnii, Eucalyptus robusta, Eucalyptus tereticornis e Hovenia dulcis submetidas ao ensaio de apodrecimento acelerado em laboratório com os fungos Gloeophyllum ...
Douglas Edson Carvalho, Elio José Santini, Fernando Nunes Gouveia, Márcio Pereira da Rocha   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Ability of selected basidiomycetous fungi to decay black locust wood

Drewno
Black locust (Robinia pseudoacacia L.) is a non-native tree species wide-spread all over Europe that has already gained some commercial importance. The study assessed ability of selected basidiomycetous fungi (Coniophora puteana, Heterobasidion annosum ...
Andrzej Szczepkowski, Ewa Referowska, Hubert Lachowicz, Szymon Bijak   +3 more
doaj   +1 more source

Evaluation of Structural Mortars Made with Mixed Recycled Aggregates with Different Composition

Revista Cubana de Ingeniería, 2013
In the present study are analyzed the mechanical and durability properties of structural mortars made with total replacement of natural aggregates by recycled aggregates.
Iván Martínez Herrera, Elier Pavón de la Fé, Nelson Díaz Brito   +2 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Durability of self-consolidating concrete containing natural waste perlite powders

Heliyon, 2020
Perlite is a natural glassy volcanic rock used in construction applications requiring improved lightweight, thermal, and acoustic properties. During processing of raw perlite (i.e., cutting and fractioning to different sizes), large amounts of powders ...
Abdulkader El Mir, Salem G. Nehme, Joseph J. Assaad   +2 more
doaj   +1 more source

Determination of anisotropy to enhance the durability of natural stone [PDF]

Journal of Geophysics and Engineering, 2011
Anisotropy is a petrophysical property of natural stone and other construction materials that determines their quality and resistance to decay due to a variety of agents, such as water. A study was conducted on nine types of stone widely used in Spain's built heritage, using six previously defined anisotropy indices.
Fort González, Rafael, Varas, María José, Álvarez de Buergo, Mónica, Freire, D. M.   +3 more
openaire   +2 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Biological Resistance of Two Reforestation Woods to Dry Wood Termites

Floresta e Ambiente
This work aimed to evaluate the biological resistance of Australian red cedar (Toona ciliata) and Eucalyptus woods to the Cryptotermes brevis (Kalotermitidae) dry wood termite species.
José Tarcisio da Silva Oliveira, Juarez Benigno Paes   +1 more
doaj   +1 more source