Results 81 to 90 of about 11,921,961 (287)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Risk assessment of lead and cadmium on Juveniles of Cyprinus carpio in laboratory scale

Vietnam Journal of Science, Technology and Engineering, 2018
This paper assesses the risk of lead and cadmium heavy metals on Cyprinus carpio in laboratory conditions. The research determined the 96 hours LC50 value of lead nitrate and cadmium nitrate in the fish Cyprinus carpio.
Thi Yen Ta, Thi Trinh Le, Thi Thuy Trinh, Thi Tham Trinh, Thi Mai Thao Pham, Thi Hong Phuong Pham   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

HALLAZGO DE OOFAGIA CANIBALÍSTICA EN PELTOCEPHALUS DUMERILIANUS: (TESTUDINES: PODOCNEMIDIDAE) DISCOVERY OF CANNIBALISTIC OOPHAGY IN PELTOCEPHALUS DUMERILIANUS: (TESTUDINES: PODOCNEMIDIDAE)

Actualidades Biológicas, 2009
Se presenta por primera vez el hallazgo de oofagia canibalística en Peltocephalus dumerilianus (Schweigger, 1812) (Testudines: Podocnemididae), detectada durante un estudio de dieta en medio natural para esta especie, en el cual se examinaron muestras de
Jaime De La Ossa V., Richard C. Vogt, Alejandro De La Ossa Lacayo   +2 more
doaj  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Emotional regulation and self-perceived quality of life in high-performance mountain sports athletes

Frontiers in Psychology
Emotional regulation is an indispensable capacity for human beings, so that alterations in it can lead to the appearance of psychological, social and/or cognitive disorders. Therefore, possessing adequate emotional strategies is intimately related to the
Pablo Rojo-Ramos, Carmen Galán-Arroyo, Santiago Gómez-Paniagua, Antonio Castillo-Paredes, Jorge Rojo-Ramos   +4 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Detection of Citrus Huanglongbing in Natural Field Conditions Using an Enhanced YOLO11 Framework

Mathematics
Citrus Huanglongbing (HLB) is one of the most devastating diseases in the global citrus industry, but its early detection under complex field conditions remains a major challenge. Existing methods often suffer from insufficient dataset diversity and poor
Liang Cao, Wei Xiao, Zeng Hu, Xiangli Li, Zhongzhen Wu   +4 more
doaj   +1 more source