Results 101 to 110 of about 7,017,113 (243)

Comparative analysis of the ex vivo IFN-gamma responses to CD8+ T cell epitopes within allelic forms of PfAMA1 in subjects with natural exposure to malaria. [PDF]

PLoS One, 2021
Nlinwe ON, Ofori EA, Akyea-Mensah K, Kyei-Baafour E, Ganeshan H, Belmonte M, Peters B, Villasante E, Sedegah M, Kusi KA.   +9 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

A general guide to the American Museum of Natural History. (Guide leaflet, no. 13)

, 1904
54 p. : ill., map ; 25 cm.Supplement to: American Museum journal, v. 4, no. 1, Jan. 1904. Subsequently published as: General guide to the exhibition halls of the American Museum of Natural History, [1st ed.] (1911)
American Museum of Natural History.
core   +1 more source

Information about lead exposure in Clarksburg, West Virginia [PDF]

info-lead-exposure-clarksburg-wv-may-2022-508 ...

core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression

Signal Transduction and Targeted Therapy, 2021
Yi Zhao, Nayeon Shim, Yan-Hong Cui, Jae-Hyeok Kang, Ki-Chun Yoo, Seungmo Kim, Joo Mi Yi, Min-Jung Kim, Jai Hoon Yoon, Su-Jae Lee   +9 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Loss of FBXL14 promotes mesenchymal shift and radioresistance of non-small cell lung cancer by TWIST1 stabilization

Signal Transduction and Targeted Therapy, 2021
Yan-Hong Cui, Jae-Hyeok Kang, Yongjoon Suh, Yi Zhao, Joo Mi Yi, In-Hwa Bae, Hae-June Lee, Dong Won Park, Min-Jung Kim, Su-Jae Lee   +9 more
doaj   +1 more source

The applicability of pig oral fluid in laboratory diagnostics of porcine reproductive and respiratory syndrome and its effectiveness in controlled exposure of gilts

Frontiers in Veterinary Science
BackgroundPorcine reproductive and respiratory syndrome (PRRS) remain a major challenge for swine health and production, and effective control depends on successful acclimation of replacement gilts.
Jan Plut, Marek Brabec, Marina Štukelj
doaj   +1 more source