Results 31 to 40 of about 7,017,113 (243)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Ascending to Well-Being through Mediated Spaces: An Alternative to Informal Learning and Physical Activity Environments in Vertical Schools

Architecture
The correlation between health and well-being, outdoor activity, and the natural environment in learning environments has been recognised by pioneers like Samuel Wilderspin and modern theorists like Maria Montessori, who have underscored the importance ...
Elia Ebrahimi Salari, Nigel Westbrook
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

24/7 population modelling for enhanced assessment of exposure to natural hazards

, 2013
There is a growing need for accurate spatio-temporal population estimates free from arbitrary administrative boundaries and temporal divisions to make enhanced assessments of population exposure to natural hazards. The approach proposed here combines the
Martin, David, Smith, Alan, Cockings, Samantha   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

EXPERIENCE OF THE CONTINUING PROFESSIONAL EDUCATION ACTIVITY MANAGEMENT AT THE INSTITUTE OF RADIATION HYGIENE

Радиационная гигиена, 2015
Results of the Institute of Radiation Hygiene educational activity during two and a half year since receiving a license are addressed in the article. Possibilities and approaches to the conduction of traditional and some unique training cycles are shown.
T. P. Simonova
doaj  

Incorporating weather in counts and trends of migrating Common Nighthawks

Avian Conservation and Ecology
Effective conservation planning for species of concern requires long-term monitoring data that can accurately estimate population trends. Supplemental or alternative methods for estimating population trends are necessary for species that are poorly ...
Stephen R Kolbe, Gerald J Niemi, Annie M Bracey, Matthew A Etterson, Alexis R Grinde   +4 more
doaj   +1 more source