Results 51 to 60 of about 7,312,015 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

EXPERIENCE OF THE CONTINUING PROFESSIONAL EDUCATION ACTIVITY MANAGEMENT AT THE INSTITUTE OF RADIATION HYGIENE

Радиационная гигиена, 2015
Results of the Institute of Radiation Hygiene educational activity during two and a half year since receiving a license are addressed in the article. Possibilities and approaches to the conduction of traditional and some unique training cycles are shown.
T. P. Simonova
doaj  

Incorporating weather in counts and trends of migrating Common Nighthawks

Avian Conservation and Ecology
Effective conservation planning for species of concern requires long-term monitoring data that can accurately estimate population trends. Supplemental or alternative methods for estimating population trends are necessary for species that are poorly ...
Stephen R Kolbe, Gerald J Niemi, Annie M Bracey, Matthew A Etterson, Alexis R Grinde   +4 more
doaj   +1 more source

Nature in VR: A Multisensory Perspective of Artificial Nature Exposure

, 2023
A virtual environment can offer a highly immersive experience with a feeling of presence similar to the physical world. Nevertheless, it still lacks several multisensory and emotional properties to fully substitute or replicate the physical world's richness and complexity.
Mossberg, Alfred, Wall, Kristoffer
openaire   +2 more sources

Investigation of Natural Effective Gamma Dose Rates case study: Ardabil Province in Iran [PDF]

Gamma rays pose enough energy to form charged particles and adversely affect human health. Since, the external exposure of human beings to natural environmental gamma radiation normally exceeds that from all man-made sources combined, natural background ...
زیوری, سحر, صادقی, هادی, Sahar Zivari, Soheila Rahimzadeh, حضرتی, صادق, رحیم زاده, سهیلا, Manouchehr Barak, Abbas Baghi, Hadi Sadeghi, براک, منوچهر, Sadegh Hazrati, نقی زاده باقی, عباس   +11 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Exposure to nature through an urban natural monument

International Journal of Evaluation and Research in Education (IJERE)
<span>Society is experiencing a decrease in opportunities to connect with nature, <br /> a problem that is particularly acute during childhood. Numerous studies indicate that increasing the frequency of participation in nature-related activities in urban environments, through elements such as interpretive trails and sensory trails, improves
Isabel María Muñoz-García, Jorge Alcántara-Manzanares, Jerónimo Torres-Porras   +2 more
openaire   +4 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Systemic cytokine signatures associated with volcanic emisions exposure and respiratory disease after the cumbre vieja eruption-ashes project

Ecotoxicology and Environmental Safety
Introduction: In September 2021, the eruption of the Tajogaite volcano on La Palma (Spain) released large amounts of toxic gases and particulate matter over three months.
Victor Guerra-Ruiz, David Díaz-Pérez, David Soler-Segovia, Cristina Candal-Pedreira, Valle Velasco-González, Ciro Casanova-Macario, Esther Barreiro, Ana Cañas, Francisco-Javier Sánchez-Iñigo-Javier, Alberto Ruano-Raviña, María-Jesús Cruz, Xavier Muñoz   +11 more
doaj   +1 more source