Results 61 to 70 of about 470,796 (264)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Environmental values in the petrochemical industry: A Q-method study in South West Iran

Environmental & Socio-economic Studies, 2015
Achieving sustainable development in different regional and cultural contexts is dependent, in part, upon an understanding of key actors’ underlying environmental, social and economic values. The social research technique called Q-methodology presents an
Ghoochani Omid M., Bakhshi Azadeh, Cotton Matthew, Nejad Azar Hashemi, Ghanian Mansour   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Evaluation of yield and stability of sugar beet (beta vulgaris L.) genotypes using GGE biplot and AMMI analysis

Scientific Reports
Rhizomania is the most destructive sugar beet disease in the world, and in recent years, it has widespread in most of the sugar beet growing areas in Iran.
Vali-allah Yousefabadi, Parviz Mehdikhani, Fathollah Nadali, Mastaneh Sharifi, Heydar Azizi, Masoud Ahmadi, Parviz Fasahat   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Analysis of Communicative Factors Affecting in Application of Sustainable Rice Farming Practices among Paddy Farmers of Mazandaran Province [PDF]

International Journal of Agricultural Management and Development, 2015
The main purpose of this study was to analyze of communicative factors affecting in application of Sustainable Rice Farming Practices among paddy farmers of Mazandaran province.
Laleh Salehi, Ahmad Rezvanfar, Seyed Hamid Movahed Mohammadi, Seyed Mahmood Hosseini   +3 more
doaj   +1 more source

Gentzenizing Schroeder-Heister's natural extension of natural deduction.

Notre Dame Journal of Formal Logic, 1989
Our purpose here is to provide an example of how the use of the Gentzen-type sequential calculus considerably simplifies a complex Natural Deduction formalism. The formalism is that of Schroeder-Heister's system of higher-order rules. We show that the notions of Schroeder-Heister's that are the most difficult to handle become rebundant in the Gentzen ...
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Coexisting burden of maternal and child undernutrition in Ethiopia: a systematic review and meta-analysis

Systematic Reviews
Background Maternal and child undernutrition is one of the contemporary pervasive and pressing public health crises in developing country, like Ethiopia.
Getasew Daru Tariku, Senkie Alemu Kebede, Tadsual Asfaw Dessie, Abebaw Abebe Getahun   +3 more
doaj   +1 more source