Results 71 to 80 of about 470,796 (264)

Climate adaptation needs of Asian farmers in the Central Coast of California

Frontiers in Sustainable Food Systems
Small-scale farmers in California are more vulnerable to adverse climate and weather related impacts, yet there is limited research on their climate adaptation needs. In this study, we conducted a needs assessment to address the gap on climate adaptation
Lauren O. Pong, Samuel Ikendi, Vikram Koundinya, Vikram Koundinya, Aparna Gazula, Tapan B. Pathak, Tapan B. Pathak   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Modeling the Relationship Between Concerns and Environmental Attitudes Among Students, University of Agricultural Sciences and Natural Resources Khuzestan, Iran [PDF]

محیط زیست و مهندسی آب
One of the desirable solutions to overcome environmental challenges is the education and training of academic-educated human resources holding an environmental perspective.
Abolmohammad Bondori, Masoumeh Forozani, Fatemeh Ghasemzadeh   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Investigating the Willingness of Farmers to Implement the Cultivation Pattern Proposed by the Ministry of Agriculture-Jahad to Improve the Employment Situation [PDF]

راهبردهای کارآفرینی در کشاورزی
Extended Abstract Background: Sustainable agricultural development and sustainable food security require the protection of basic resources, including soil, water, etc. The cultivation pattern of agricultural products plays an important role in protecting
Taher Azizi-khalkheili, Meysam Menatizadeh, Fatemeh Razaghi-bourkhani   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Stakeholder agricultural priorities and contextual realities that should shape extension and advisory services for agroecological transitions in Malawi

Discover Sustainability
Studies explaining the slow agroecological transitions of farms in many parts of the world have largely focused on prescribing how extension and advisory services (EAS) should adapt to agroecology.
Limson Kaluzi, Daimon Kambewa, Isaac Mambo   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Indefinite Extensibility in Natural Language [PDF]

Monist, 2013
ABSTRACTThe Monist's call for papers for this issue ended: "If formalism is true, then it must be possible in principle to mechanize meaning in a conscious thinking and language-using machine; if intentionalism is true, no such project is intelligible." We use the Grelling-Nelson paradox to show that natural language is indefinitely extensible, which ...
openaire   +1 more source