Results 61 to 70 of about 3,804,515 (284)

First Integrals of Extended Hamiltonians in n+1 Dimensions Generated by Powers of an Operator

Symmetry, Integrability and Geometry: Methods and Applications, 2011
We describe a procedure to construct polynomial in the momenta first integrals of arbitrarily high degree for natural Hamiltonians H obtained as one-dimensional extensions of natural (geodesic) n-dimensional Hamiltonians L. The Liouville integrability of
Giovanni Rastelli, Luca Degiovanni, Claudia Chanu   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Borel–Cantelli Lemma for Capacities

Mathematics
In this paper, we investigate the second Borel–Cantelli lemma for capacity without the assumption of independence for events. We obtain a sufficient condition under which the second Borel–Cantelli lemma for capacity holds.
Chunyu Kao, Gaofeng Zong
doaj   +1 more source

Subjective Expected Utility with State-Dependent but Action/Observation-Independent Preferences

Risks, 2018
Under state-dependent preferences, probabilities and units of scale of state-dependent utilities are not separately identified. In standard models, only their products matter to decisions.
Jacques H. Drèze
doaj   +1 more source

How students learn from multiple contexts and definitions: Proper time as a coordination class

Physical Review Special Topics. Physics Education Research, 2008
This article provides an empirical analysis of a single classroom episode in which students reveal difficulties with the concept of proper time in special relativity but slowly make progress in improving their understanding.
Olivia Levrini, Andrea A. diSessa
doaj   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Predictive Fingerstroke-Level Model for Smartwatch Interaction

Multimodal Technologies and Interaction, 2018
The keystroke-level model (KLM) is commonly used to predict the time it will take an expert user to accomplish a task without errors when using an interactive system.
Shiroq Al-Megren
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Gentzenizing Schroeder-Heister's natural extension of natural deduction.

Notre Dame Journal of Formal Logic, 1989
Our purpose here is to provide an example of how the use of the Gentzen-type sequential calculus considerably simplifies a complex Natural Deduction formalism. The formalism is that of Schroeder-Heister's system of higher-order rules. We show that the notions of Schroeder-Heister's that are the most difficult to handle become rebundant in the Gentzen ...
openaire   +3 more sources