Results 81 to 90 of about 3,804,515 (284)

Long actin-based cellular protrusions as novel evidence of the cytopathic effect induced in immune cells infected by the ectromelia virus

Central European Journal of Immunology, 2018
The aim of the study was to evaluate the influence of ectromelia virus (ECTV) infection on actin cytoskeleton rearrangement in immune cells, such as macrophages and dendritic cells (DCs).
Lidia Szulc-Dąbrowska, Karolina P. Gregorczyk-Zboroch, Justyna Struzik, Zbigniew Wyżewski, Agnieszka Ostrowska, Felix N. Toka, Małgorzata Gieryńska   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Some Identities Involving Derangement Polynomials and Numbers and Moments of Gamma Random Variables

Journal of Function Spaces, 2020
The problem of counting derangements was initiated by Pierre Rémond de Montmort in 1708. A derangement is a permutation that has no fixed points, and the derangement number Dn is the number of fixed point free permutations on an n element set ...
Lee-Chae Jang, Dae San Kim, Taekyun Kim, Hyunseok Lee   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Improved cooling of photovoltaic panels by natural convection flow in a channel with adiabatic extensions.

PLoS ONE
In hot dry regions, photovoltaic modules are exposed to excessive temperatures, which leads to a drop in performance and the risk of overheating. The present numerical study aims to evaluate the natural air cooling of PV modules by an inclined chimney ...
Nacer Badi, Ali Hatem Laatar
doaj   +1 more source

Indefinite Extensibility in Natural Language [PDF]

Monist, 2013
ABSTRACTThe Monist's call for papers for this issue ended: "If formalism is true, then it must be possible in principle to mechanize meaning in a conscious thinking and language-using machine; if intentionalism is true, no such project is intelligible." We use the Grelling-Nelson paradox to show that natural language is indefinitely extensible, which ...
openaire   +1 more source

Brand gender and cross-gender extensions. [PDF]

Afin de se développer et de générer des profits, la plupart des marques de luxe utilisent les stratégies d’extension de marque, c'est-à-dire qu’elles essaient de s’introduire dans de nouvelles catégories de produits.
Nyeck, Simon, Veg, Nathalie
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source