Results 41 to 50 of about 84,052 (266)

Genetic Diversity of Siberian Isolates of Borrelia burgdorferi Sensu Lato by the ospA Gene

Microorganisms
The genetic diversity of the ospA gene of the Borrelia burgdorferi sensu lato species complex encoding outer surface protein A has been widely investigated.
Yana Igolkina, Vera Rar, Valeriy Yakimenko, Alevtina Bardasheva, Valeria Fedorets, Alfrid Karimov, Gavril Rubtsov, Tamara Epikhina, Nina Tikunova   +8 more
doaj   +1 more source

Prognostication of Epizootiologic Activity of Plague Natural Foci the Russian Federation for 2008

Проблемы особо опасных инфекций, 2008
A short-term prognosis of plague epizootic activity in 11 natural foci in the Russian Federation for 2008 is substantiated by the authors. The present situation with the numbers of the main carriers and vectors of plague infection in diverse types of ...
N. V. Popov, V. E. Bezsmertny, N. L. Novikov, A. I. Udovikov, A. A. Kouznetsov, V. N. Popov, L. D. Shilova, V. V. Kutyrev   +7 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Epidemiological Situation on Tularemia in the far Eastern Federal District (2000-2017)

Эпидемиология и вакцинопрофилактика, 2019
Relevance Tularemia - natural focal zoonotic infection occupies an important place in the structure of human infectious pathology. The incidence is associated with natural foci, where there are favorable conditions for the existence of the pathogen, its ...
T. N. Demidova, V. P Popov, T. V. Mikhailova, A. S. Cemichin, Y. S. Podobedova   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epizootic Activity of Natural Plague Foci in the Russian Federation in 2012 and Prognosis for the Year of 2013

Проблемы особо опасных инфекций, 2013
Integrated are the data on the number of major carriers and vectors as well as the epizootic activity of natural foci of plague of different types in the territory of Russia in 2012.
N. V. Popov, V. E. Bezsmertny, V. P. Toporkov, A. A. Kuznetsov, A. N. Matrosov, T. V. Knyazeva, V. P. Popov, D. B. Verzhutsky, V. M. Korzun, E. V. Chipanin, V. M. Dubyansky, O. V. Maletskaya, M. P. Grigoryev, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +15 more
doaj   +1 more source

Zoologist Alekseev Anatoly Fedorovich (Crimean period of his life) [PDF]

Novitates Theriologicae, 2022
An essay about a researcher who had developed professionally in Central Asia, where he worked for a quarter of a century in the Karakalpak branch of the Uzbek Anti-plague Station studying natural foci of plague.
Igor Evstafiev
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source