Results 91 to 100 of about 12,187,245 (343)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

FBG-Based Accelerometer for Buried Pipeline Natural Frequency Monitoring and Corrosion Detection

open access: yesBuildings
Pipelines are structures with great relevance in different industrial sectors and are essential for the proper functioning of the logistics that support today’s society.
Luís Pereira   +7 more
doaj   +1 more source

DAMAGE DETECTION IN COMPOSITE CYLINDRICAL PANEL BASED ON FORCED VIBRATION ANALYSIS [PDF]

open access: yesScientific Journal of Silesian University of Technology. Series Transport, 2014
The current work is devoted to the damage detecting inside the composite cylindrical panels. The applied method is based on the analysis of the natural vibration and corresponding mode shapes.
Piotr PAJĄK, Marek BARSKI
doaj  

Thermo-Hygral Analysis on Long-Term Natural Frequency of RC Buildings with Different Dimensions

open access: yes, 2017
Gradual decay of natural frequency of reinforced concrete (RC) buildings is computationally investigated in view of the long-term moisture loss and associated shrinkage of concrete.
Ryo Kurihara, N. Chijiwa, K. Maekawa
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Experimental Verification of a Compressor Drive Simulation Model to Minimize Dangerous Vibrations

open access: yesApplied Sciences
The article highlights the importance of analytical computational models of torsionally oscillating systems and their simulation for estimating the lowest resonance frequencies.
Marek Moravič   +5 more
doaj   +1 more source

A High Performance Sensor for Triaxial Cutting Force Measurement in Turning

open access: yesSensors, 2015
This paper presents a high performance triaxial cutting force sensor with excellent accuracy, favorable natural frequency and acceptable cross-interference for high speed turning process.
You Zhao   +3 more
doaj   +1 more source

Effect of Thrust on the Structural Vibrations of a Nonuniform Slender Rocket

open access: yesMathematical and Computational Applications, 2020
The vibration characteristics of a nonuniform, flexible and free-flying slender rocket experiencing constant thrust is investigated. The rocket is idealized as a classic nonuniform beam with a constant one-dimensional follower force and with free-free ...
Desmond Adair   +2 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

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