Results 81 to 90 of about 3,531,996 (294)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Efroimsky formalism adapted to high-frequency perturbations

, 2004
The Efroimsky perturbation scheme for consistent treatment of gravitational waves and their influence on the background is summarized and compared with classical Isaacson's high-frequency approach.
Anderson P R, Araujo M E, Araujo M E, Burnett G A, Choquet-Bruhat Y, Efroimsky M, Efroimsky M, Elster T, Hogan P A, J Podolský, MacCallum M A H, O Svítek, Podolský J, Taub A H, Taub A H, Wheeler J A   +15 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

FBG-Based Accelerometer for Buried Pipeline Natural Frequency Monitoring and Corrosion Detection

Buildings
Pipelines are structures with great relevance in different industrial sectors and are essential for the proper functioning of the logistics that support today’s society.
Luís Pereira, Israel Sousa, Esequiel Mesquita, Antônio Cabral, Nélia Alberto, Camilo Diaz, Humberto Varum, Paulo Antunes   +7 more
doaj   +1 more source

DAMAGE DETECTION IN COMPOSITE CYLINDRICAL PANEL BASED ON FORCED VIBRATION ANALYSIS [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2014
The current work is devoted to the damage detecting inside the composite cylindrical panels. The applied method is based on the analysis of the natural vibration and corresponding mode shapes.
Piotr PAJĄK, Marek BARSKI
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Experimental Verification of a Compressor Drive Simulation Model to Minimize Dangerous Vibrations

Applied Sciences
The article highlights the importance of analytical computational models of torsionally oscillating systems and their simulation for estimating the lowest resonance frequencies.
Marek Moravič, Daniela Marasová, Peter Kaššay, Maksymilian Ozdoba, František Lopot, Piotr Bortnowski   +5 more
doaj   +1 more source

A High Performance Sensor for Triaxial Cutting Force Measurement in Turning

Sensors, 2015
This paper presents a high performance triaxial cutting force sensor with excellent accuracy, favorable natural frequency and acceptable cross-interference for high speed turning process.
You Zhao, Yulong Zhao, Songbo Liang, Guanwu Zhou   +3 more
doaj   +1 more source

Effect of Thrust on the Structural Vibrations of a Nonuniform Slender Rocket

Mathematical and Computational Applications, 2020
The vibration characteristics of a nonuniform, flexible and free-flying slender rocket experiencing constant thrust is investigated. The rocket is idealized as a classic nonuniform beam with a constant one-dimensional follower force and with free-free ...
Desmond Adair, Aigul Nagimova, Martin Jaeger   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source